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Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells.
Takata H, Kakazu JC, Mitchell JL, Kroon E, Colby DJ, Sacdalan C, Bai H, Ehrenberg PK, Geretz A, Buranapraditkun S, Pinyakorn S, Intasan J, Tipsuk S, Suttichom D, Prueksakaew P, Chalermchai T, Chomchey N, Phanuphak N, de Souza M, Michael NL, Robb ML, Haddad EK, Crowell TA, Vasan S, Valcour VG, Douek DC, Thomas R, Rolland M, Chomont N, Ananworanich J, Trautmann L; RV254/SEARCH010, RV304/ SEARCH013, and SEARCH011 study groups. Takata H, et al. Among authors: mitchell jl. EBioMedicine. 2022 Oct;84:104253. doi: 10.1016/j.ebiom.2022.104253. Epub 2022 Sep 8. EBioMedicine. 2022. PMID: 36088683 Free PMC article.
An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status.
Takata H, Mitchell JL, Pacheco J, Pagliuzza A, Pinyakorn S, Buranapraditkun S, Sacdalan C, Leyre L, Nathanson S, Kakazu JC, Intasan J, Prueksakaew P, Chomchey N, Phanuphak N, de Souza M, Haddad EK, Rolland M, Tovanabutra S, Vasan S, Hsu DC, Chomont N, Trautmann L; RV254/SEARCH010; RV304/SEARCH013. Takata H, et al. Among authors: mitchell jl. Cell Host Microbe. 2023 Sep 13;31(9):1494-1506.e4. doi: 10.1016/j.chom.2023.08.012. Cell Host Microbe. 2023. PMID: 37708852 Free PMC article.
Initial productive and latent HIV infections originate in vivo by infection of resting T cells.
Wietgrefe SW, Anderson J, Duan L, Southern PJ, Zuck P, Wu G, Howell BJ, Reilly C, Kroon E, Chottanapund S, Buranapraditkun S, Sacdalan C, Tulmethakaan N, Colby DJ, Chomchey N, Prueksakaew P, Pinyakorn S, Trichavaroj R, Mitchell JL, Trautmann L, Hsu D, Vasan S, Manasnayakorn S, de Souza M, Tovanabutra S, Schuetz A, Robb ML, Phanuphak N, Ananworanich J, Schacker TW, Haase AT; RV254/SEARCH 010 Study Team. Wietgrefe SW, et al. Among authors: mitchell jl. J Clin Invest. 2023 Nov 15;133(22):e171501. doi: 10.1172/JCI171501. J Clin Invest. 2023. PMID: 37733443 Free PMC article.
Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection.
Mitchell JL, Pollara J, Dietze K, Edwards RW, Nohara J, N'guessan KF, Zemil M, Buranapraditkun S, Takata H, Li Y, Muir R, Kroon E, Pinyakorn S, Jha S, Manasnayakorn S, Chottanapund S, Thantiworasit P, Prueksakaew P, Ratnaratorn N, Nuntapinit B, Fox L, Tovanabutra S, Paquin-Proulx D, Wieczorek L, Polonis VR, Maldarelli F, Haddad EK, Phanuphak P, Sacdalan CP, Rolland M, Phanuphak N, Ananworanich J, Vasan S, Ferrari G, Trautmann L; RV254 and RV304 Study Groups. Mitchell JL, et al. J Clin Invest. 2022 Jan 4;132(1):e150937. doi: 10.1172/JCI150937. J Clin Invest. 2022. PMID: 34762600 Free PMC article. Clinical Trial.
HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections.
Gantner P, Buranapraditkun S, Pagliuzza A, Dufour C, Pardons M, Mitchell JL, Kroon E, Sacdalan C, Tulmethakaan N, Pinyakorn S, Robb ML, Phanuphak N, Ananworanich J, Hsu D, Vasan S, Trautmann L, Fromentin R, Chomont N. Gantner P, et al. Among authors: mitchell jl. Immunity. 2023 Mar 14;56(3):653-668.e5. doi: 10.1016/j.immuni.2023.01.030. Epub 2023 Feb 17. Immunity. 2023. PMID: 36804957 Free PMC article.
Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption.
Mitchell JL, Takata H, Muir R, Colby DJ, Kroon E, Crowell TA, Sacdalan C, Pinyakorn S, Puttamaswin S, Benjapornpong K, Trichavaroj R, Tressler RL, Fox L, Polonis VR, Bolton DL, Maldarelli F, Lewin SR, Haddad EK, Phanuphak P, Robb ML, Michael NL, de Souza M, Phanuphak N, Ananworanich J, Trautmann L; RV397, RV411, and RV254 Study Groups. Mitchell JL, et al. J Clin Invest. 2020 Jun 1;130(6):2845-2858. doi: 10.1172/JCI130597. J Clin Invest. 2020. PMID: 32017709 Free PMC article. Clinical Trial.
A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection.
Kroon EDMB, Ananworanich J, Pagliuzza A, Rhodes A, Phanuphak N, Trautmann L, Mitchell JL, Chintanaphol M, Intasan J, Pinyakorn S, Benjapornpong K, Chang JJ, Colby DJ, Chomchey N, Fletcher JLK, Eubanks K, Yang H, Kapson J, Dantanarayana A, Tennakoon S, Gorelick RJ, Maldarelli F, Robb ML, Kim JH, Spudich S, Chomont N, Phanuphak P, Lewin SR, de Souza MS; SEARCH 019 and RV254 Study Teams. Kroon EDMB, et al. Among authors: mitchell jl. J Virus Erad. 2020 Jul 18;6(3):100004. doi: 10.1016/j.jve.2020.100004. eCollection 2020 Sep. J Virus Erad. 2020. PMID: 33251022 Free PMC article.
Continuous Prophylactic Antiretrovirals/Antiretroviral Therapy Since Birth Reduces Seeding and Persistence of the Viral Reservoir in Children Vertically Infected With Human Immunodeficiency Virus.
Massanella M, Puthanakit T, Leyre L, Jupimai T, Sawangsinth P, de Souza M, Suntarattiwong P, Kosalarksa P, Borkird T, Kanjanavanit S, Chokephaibulkit K, Hansudewechakul R, Petdachai W, Mitchell JL, Robb ML, Trautmann L, Ananworanich J, Chomont N; RV474/HIVNAT194 and RV475/HIVNAT 209 Study Groups. Massanella M, et al. Among authors: mitchell jl. Clin Infect Dis. 2021 Aug 2;73(3):427-438. doi: 10.1093/cid/ciaa718. Clin Infect Dis. 2021. PMID: 32504081 Free PMC article.
8,351 results