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The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes.
Olombrada M, Peña C, Rodríguez-Galán O, Klingauf-Nerurkar P, Portugal-Calisto D, Oborská-Oplová M, Altvater M, Gavilanes JG, Martínez-Del-Pozo Á, de la Cruz J, García-Ortega L, Panse VG. Olombrada M, et al. Nucleic Acids Res. 2020 Jun 19;48(11):6210-6222. doi: 10.1093/nar/gkaa315. Nucleic Acids Res. 2020. PMID: 32365182 Free PMC article.
Minimized natural versions of fungal ribotoxins show improved active site plasticity.
Maestro-López M, Olombrada M, García-Ortega L, Serrano-González D, Lacadena J, Oñaderra M, Gavilanes JG, Martínez-Del-Pozo Á. Maestro-López M, et al. Among authors: olombrada m. Arch Biochem Biophys. 2017 Apr 1;619:45-53. doi: 10.1016/j.abb.2017.03.002. Epub 2017 Mar 7. Arch Biochem Biophys. 2017. PMID: 28283321 Free article.
Fungal Ribotoxins: A Review of Potential Biotechnological Applications.
Olombrada M, Lázaro-Gorines R, López-Rodríguez JC, Martínez-Del-Pozo Á, Oñaderra M, Maestro-López M, Lacadena J, Gavilanes JG, García-Ortega L. Olombrada M, et al. Toxins (Basel). 2017 Feb 21;9(2):71. doi: 10.3390/toxins9020071. Toxins (Basel). 2017. PMID: 28230789 Free PMC article. Review.
Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin α-sarcin in nude mice bearing human colorectal cancer xenografts.
Tomé-Amat J, Olombrada M, Ruiz-de-la-Herrán J, Pérez-Gómez E, Andradas C, Sánchez C, Martínez L, Martínez-Del-Pozo Á, Gavilanes JG, Lacadena J. Tomé-Amat J, et al. Among authors: olombrada m. Springerplus. 2015 Apr 8;4:168. doi: 10.1186/s40064-015-0943-5. eCollection 2015. Springerplus. 2015. PMID: 25883890 Free PMC article.
Involvement of loops 2 and 3 of α-sarcin on its ribotoxic activity.
Castaño-Rodríguez C, Olombrada M, Partida-Hanon A, Lacadena J, Oñaderra M, Gavilanes JG, García-Ortega L, Martínez-Del-Pozo Á. Castaño-Rodríguez C, et al. Among authors: olombrada m. Toxicon. 2015 Mar;96:1-9. doi: 10.1016/j.toxicon.2015.01.007. Epub 2015 Jan 15. Toxicon. 2015. PMID: 25598497
Fungal ribotoxins: Natural protein-based weapons against insects.
Olombrada M, Martínez-del-Pozo A, Medina P, Budia F, Gavilanes JG, García-Ortega L. Olombrada M, et al. Toxicon. 2014 Jun;83:69-74. doi: 10.1016/j.toxicon.2014.02.022. Epub 2014 Mar 14. Toxicon. 2014. PMID: 24631599 Review.
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