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Page 1
Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro.
Salpini R, Surdo M, Warner N, Cortese MF, Colledge D, Soppe S, Bellocchi MC, Armenia D, Carioti L, Continenza F, Di Carlo D, Saccomandi P, Mirabelli C, Pollicita M, Longo R, Romano S, Cappiello G, Spanò A, Trimoulet P, Fleury H, Vecchiet J, Iapadre N, Barlattani A, Bertoli A, Mari T, Pasquazzi C, Missale G, Sarrecchia C, Orecchini E, Michienzi A, Andreoni M, Francioso S, Angelico M, Verheyen J, Ceccherini-Silberstein F, Locarnini S, Perno CF, Svicher V. Salpini R, et al. Among authors: mirabelli c. Oncotarget. 2017 Feb 28;8(9):15704-15715. doi: 10.18632/oncotarget.14944. Oncotarget. 2017. PMID: 28152517 Free PMC article.
The novel HBx mutation F30V correlates with hepatocellular carcinoma in vivo, reduces hepatitis B virus replicative efficiency and enhances anti-apoptotic activity of HBx N terminus in vitro.
Salpini R, Surdo M, Cortese MF, Palumbo GA, Carioti L, Cappiello G, Spanò A, Trimoulet P, Fleury H, Vecchiet J, Pasquazzi C, Mirabelli C, Scutari R, Sacco A, Alkhatib M, Missale G, Francioso S, Sarmati L, Andreoni M, Angelico M, Ceccherini-Silberstein F, Levrero M, Perno CF, Belloni L, Svicher V. Salpini R, et al. Among authors: mirabelli c. Clin Microbiol Infect. 2019 Jul;25(7):906.e1-906.e7. doi: 10.1016/j.cmi.2018.11.017. Epub 2018 Nov 23. Clin Microbiol Infect. 2019. PMID: 30472417 Free article.
Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Cento V, Van Hemert F, Neumann-Fraune M, Mirabelli C, Di Maio VC, Salpini R, Bertoli A, Micheli V, Gubertini G, Romano S, Visca M, De Sanctis GM, Berkhout B, Marino N, Mazzotta F, Cappiello G, Spanò A, Sarrecchia C, Ceccherini-Silberstein F, Andreoni M, Angelico M, Verheyen J, Perno CF, Svicher V. Cento V, et al. Among authors: mirabelli c. J Infect. 2013 Oct;67(4):303-12. doi: 10.1016/j.jinf.2013.05.008. Epub 2013 Jun 22. J Infect. 2013. PMID: 23796863
Specific mutations in the C-terminus domain of HBV surface antigen significantly correlate with low level of serum HBV-DNA in patients with chronic HBV infection.
Mirabelli C, Surdo M, Van Hemert F, Lian Z, Salpini R, Cento V, Cortese MF, Aragri M, Pollicita M, Alteri C, Bertoli A, Berkhout B, Micheli V, Gubertini G, Santoro MM, Romano S, Visca M, Bernassola M, Longo R, De Sanctis GM, Trimoulet P, Fleury H, Marino N, Mazzotta F, Cappiello G, Spanò A, Sarrecchia C, Zhang JM, Andreoni M, Angelico M, Verheyen J, Perno CF, Svicher V. Mirabelli C, et al. J Infect. 2015 Mar;70(3):288-98. doi: 10.1016/j.jinf.2014.10.015. Epub 2014 Nov 6. J Infect. 2015. PMID: 25452041
Overlapping structure of hepatitis B virus (HBV) genome and immune selection pressure are critical forces modulating HBV evolution.
Cento V, Mirabelli C, Dimonte S, Salpini R, Han Y, Trimoulet P, Bertoli A, Micheli V, Gubertini G, Cappiello G, Spanò A, Longo R, Bernassola M, Mazzotta F, De Sanctis GM, Zhang XX, Verheyen J, D'Arminio Monforte A, Ceccherini-Silberstein F, Perno CF, Svicher V. Cento V, et al. Among authors: mirabelli c. J Gen Virol. 2013 Jan;94(Pt 1):143-149. doi: 10.1099/vir.0.046524-0. Epub 2012 Oct 10. J Gen Virol. 2013. PMID: 23052389
HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors.
Cento V, Mirabelli C, Salpini R, Dimonte S, Artese A, Costa G, Mercurio F, Svicher V, Parrotta L, Bertoli A, Ciotti M, Di Paolo D, Sarrecchia C, Andreoni M, Alcaro S, Angelico M, Perno CF, Ceccherini-Silberstein F. Cento V, et al. Among authors: mirabelli c. PLoS One. 2012;7(7):e39652. doi: 10.1371/journal.pone.0039652. Epub 2012 Jul 6. PLoS One. 2012. PMID: 22792183 Free PMC article.
Hepatitis C virus genetic variability and the presence of NS5B resistance-associated mutations as natural polymorphisms in selected genotypes could affect the response to NS5B inhibitors.
Di Maio VC, Cento V, Mirabelli C, Artese A, Costa G, Alcaro S, Perno CF, Ceccherini-Silberstein F. Di Maio VC, et al. Among authors: mirabelli c. Antimicrob Agents Chemother. 2014 May;58(5):2781-97. doi: 10.1128/AAC.02386-13. Epub 2014 Mar 3. Antimicrob Agents Chemother. 2014. PMID: 24590484 Free PMC article.
142 results