Milligan G - Search Results

1

Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists.

Valentini A, Schultz-Knudsen K, Højgaard Hansen A, Tsakoumagkou A, Jenkins L, Christensen HB, Manandhar A, Milligan G, Ulven T, Rexen Ulven E. Valentini A, et al. Among authors: milligan g. J Med Chem. 2023 May 11;66(9):6105-6121. doi: 10.1021/acs.jmedchem.2c01935. Epub 2023 May 2. J Med Chem. 2023. PMID: 37129317 Free PMC article.

2

Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.

Canals M, Jenkins L, Kellett E, Milligan G. Canals M, et al. Among authors: milligan g. J Biol Chem. 2006 Jun 16;281(24):16757-67. doi: 10.1074/jbc.M601121200. Epub 2006 Apr 11. J Biol Chem. 2006. PMID: 16611642 Free article.

3

Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.

Stoddart LA, Smith NJ, Jenkins L, Brown AJ, Milligan G. Stoddart LA, et al. Among authors: milligan g. J Biol Chem. 2008 Nov 21;283(47):32913-24. doi: 10.1074/jbc.M805601200. Epub 2008 Sep 18. J Biol Chem. 2008. PMID: 18801738 Free article.

4

Selectivity and functional consequences of interactions of family A G protein-coupled receptors with neurochondrin and periplakin.

Ward RJ, Jenkins L, Milligan G. Ward RJ, et al. Among authors: milligan g. J Neurochem. 2009 Apr;109(1):182-92. doi: 10.1111/j.1471-4159.2009.05918.x. Epub 2009 Jan 23. J Neurochem. 2009. PMID: 19166508 Free article.

5

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.

Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G. Smith NJ, et al. Among authors: milligan g. J Biol Chem. 2009 Jun 26;284(26):17527-39. doi: 10.1074/jbc.M109.012849. Epub 2009 Apr 27. J Biol Chem. 2009. PMID: 19398560 Free PMC article.

6

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

Jenkins L, Brea J, Smith NJ, Hudson BD, Reilly G, Bryant NJ, Castro M, Loza MI, Milligan G. Jenkins L, et al. Among authors: milligan g. Biochem J. 2010 Dec 15;432(3):451-9. doi: 10.1042/BJ20101287. Biochem J. 2010. PMID: 20919992

7

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

Jenkins L, Alvarez-Curto E, Campbell K, de Munnik S, Canals M, Schlyer S, Milligan G. Jenkins L, et al. Among authors: milligan g. Br J Pharmacol. 2011 Feb;162(3):733-48. doi: 10.1111/j.1476-5381.2010.01082.x. Br J Pharmacol. 2011. PMID: 20958291 Free PMC article.

8

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T. Schmidt J, et al. Among authors: milligan g. J Biol Chem. 2011 Mar 25;286(12):10628-40. doi: 10.1074/jbc.M110.210872. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220428 Free PMC article.

9

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.

Smith NJ, Ward RJ, Stoddart LA, Hudson BD, Kostenis E, Ulven T, Morris JC, Tränkle C, Tikhonova IG, Adams DR, Milligan G. Smith NJ, et al. Among authors: milligan g. Mol Pharmacol. 2011 Jul;80(1):163-73. doi: 10.1124/mol.110.070789. Epub 2011 Apr 15. Mol Pharmacol. 2011. PMID: 21498659 Free PMC article.

10

Discovery of a potent and selective GPR120 agonist.

Shimpukade B, Hudson BD, Hovgaard CK, Milligan G, Ulven T. Shimpukade B, et al. Among authors: milligan g. J Med Chem. 2012 May 10;55(9):4511-5. doi: 10.1021/jm300215x. Epub 2012 May 2. J Med Chem. 2012. PMID: 22519963

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