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Interleukin 6 (IL6) level is a biomarker for functional disease progression within IL6R358Ala variant groups in amyotrophic lateral sclerosis patients.
Wosiski-Kuhn M, Caress JB, Cartwright MS, Hawkins GA, Milligan C. Wosiski-Kuhn M, et al. Among authors: milligan c. Amyotroph Lateral Scler Frontotemporal Degener. 2021 May;22(3-4):248-259. doi: 10.1080/21678421.2020.1813310. Epub 2020 Sep 14. Amyotroph Lateral Scler Frontotemporal Degener. 2021. PMID: 32924606
IL6 receptor358Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis.
Wosiski-Kuhn M, Robinson M, Strupe J, Arounleut P, Martin M, Caress J, Cartwright M, Bowser R, Cudkowicz M, Langefeld C, Hawkins GA, Milligan C. Wosiski-Kuhn M, et al. Among authors: milligan c. Neurol Neuroimmunol Neuroinflamm. 2019 Oct 14;6(6):e631. doi: 10.1212/NXI.0000000000000631. Print 2019 Nov. Neurol Neuroimmunol Neuroinflamm. 2019. PMID: 31611269 Free PMC article.
Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients.
Milligan C, Atassi N, Babu S, Barohn RJ, Caress JB, Cudkowicz ME, Evora A, Hawkins GA, Wosiski-Kuhn M, Macklin EA, Shefner JM, Simmons Z, Bowser RP, Ladha SS. Milligan C, et al. Muscle Nerve. 2021 Sep;64(3):309-320. doi: 10.1002/mus.27339. Epub 2021 Jun 24. Muscle Nerve. 2021. PMID: 34075589 Free PMC article. Clinical Trial.
238 results