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Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling.
Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC. Rahaman MM, et al. Among authors: miller mp. Circ Res. 2017 Jul 7;121(2):137-148. doi: 10.1161/CIRCRESAHA.117.310705. Epub 2017 Jun 5. Circ Res. 2017. PMID: 28584062 Free PMC article.
Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.
Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE. Straub AC, et al. Among authors: miller mp. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2594-600. doi: 10.1161/ATVBAHA.114.303974. Epub 2014 Oct 2. Arterioscler Thromb Vasc Biol. 2014. PMID: 25278292 Free PMC article.
Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.
Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Rahaman MM, et al. Among authors: miller mp. J Biol Chem. 2015 Jul 3;290(27):16861-72. doi: 10.1074/jbc.M114.629964. Epub 2015 May 22. J Biol Chem. 2015. PMID: 26001785 Free PMC article.
Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction.
Alvarez RA, Miller MP, Hahn SA, Galley JC, Bauer E, Bachman T, Hu J, Sembrat J, Goncharov D, Mora AL, Rojas M, Goncharova E, Straub AC. Alvarez RA, et al. Among authors: miller mp. Am J Respir Cell Mol Biol. 2017 Dec;57(6):733-744. doi: 10.1165/rcmb.2016-0418OC. Am J Respir Cell Mol Biol. 2017. PMID: 28800253 Free PMC article.
Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation.
Yuan S, Hahn SA, Miller MP, Sanker S, Calderon MJ, Sullivan M, Dosunmu-Ogunbi AM, Fazzari M, Li Y, Reynolds M, Wood KC, St Croix CM, Stolz D, Cifuentes-Pagano E, Navas P, Shiva S, Schopfer FJ, Pagano PJ, Straub AC. Yuan S, et al. Among authors: miller mp. Redox Biol. 2021 Nov;47:102166. doi: 10.1016/j.redox.2021.102166. Epub 2021 Oct 14. Redox Biol. 2021. PMID: 34656824 Free PMC article.
FoxO4 controls sGCβ transcription in vascular smooth muscle.
Galley JC, Miller MP, Sanker S, Liu M, Sharina I, Martin E, Gomez D, Straub AC. Galley JC, et al. Among authors: miller mp. Am J Physiol Heart Circ Physiol. 2022 Mar 1;322(3):H417-H426. doi: 10.1152/ajpheart.00551.2021. Epub 2022 Jan 28. Am J Physiol Heart Circ Physiol. 2022. PMID: 35089807 Free PMC article.
118 results