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Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.
Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. Sagan SA, et al. Among authors: miller cn. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14781-14786. doi: 10.1073/pnas.1617859114. Epub 2016 Dec 8. Proc Natl Acad Sci U S A. 2016. PMID: 27940915 Free PMC article.
Insights into immune tolerance from AIRE deficiency.
Proekt I, Miller CN, Lionakis MS, Anderson MS. Proekt I, et al. Among authors: miller cn. Curr Opin Immunol. 2017 Dec;49:71-78. doi: 10.1016/j.coi.2017.10.003. Epub 2017 Oct 21. Curr Opin Immunol. 2017. PMID: 29065385 Free PMC article. Review.
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. Miller CN, et al. Nature. 2018 Jul;559(7715):627-631. doi: 10.1038/s41586-018-0345-2. Epub 2018 Jul 18. Nature. 2018. PMID: 30022164 Free PMC article.
Thymic regulatory T cells arise via two distinct developmental programs.
Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA. Owen DL, et al. Among authors: miller cn. Nat Immunol. 2019 Feb;20(2):195-205. doi: 10.1038/s41590-018-0289-6. Epub 2019 Jan 14. Nat Immunol. 2019. PMID: 30643267 Free PMC article.
141 results