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Novel antiinflammatory biologics shaped by parasite-host coevolution.
Ryan SM, Ruscher R, Johnston WA, Pickering DA, Kennedy MW, Smith BO, Jones L, Buitrago G, Field MA, Esterman AJ, McHugh CP, Browne DJ, Cooper MM, Ryan RYM, Doolan DL, Engwerda CR, Miles K, Mitreva M, Croese J, Rahman T, Alexandrov K, Giacomin PR, Loukas A. Ryan SM, et al. Among authors: miles k. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2202795119. doi: 10.1073/pnas.2202795119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037362 Free PMC article.
A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis.
Buitrago G, Pickering D, Ruscher R, Cobos Caceres C, Jones L, Cooper M, Van Waardenberg A, Ryan S, Miles K, Field M, Dredge K, Daly NL, Giacomin PR, Loukas A. Buitrago G, et al. Among authors: miles k. Transl Res. 2021 Jun;232:88-102. doi: 10.1016/j.trsl.2021.02.012. Epub 2021 Mar 4. Transl Res. 2021. PMID: 33676036 Free article.
Systemic administration of IL-33 induces a population of circulating KLRG1hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma.
Guillerey C, Stannard K, Chen J, Krumeich S, Miles K, Nakamura K, Smith J, Yu Y, Ng S, Harjunpää H, Teng MW, Engwerda C, Belz GT, Smyth MJ. Guillerey C, et al. Among authors: miles k. Immunol Cell Biol. 2021 Jan;99(1):65-83. doi: 10.1111/imcb.12390. Epub 2020 Sep 18. Immunol Cell Biol. 2021. PMID: 32748462
TIGIT immune checkpoint blockade restores CD8+ T-cell immunity against multiple myeloma.
Guillerey C, Harjunpää H, Carrié N, Kassem S, Teo T, Miles K, Krumeich S, Weulersse M, Cuisinier M, Stannard K, Yu Y, Minnie SA, Hill GR, Dougall WC, Avet-Loiseau H, Teng MWL, Nakamura K, Martinet L, Smyth MJ. Guillerey C, et al. Among authors: miles k. Blood. 2018 Oct 18;132(16):1689-1694. doi: 10.1182/blood-2018-01-825265. Epub 2018 Jul 9. Blood. 2018. PMID: 29986909 Free article.
Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model.
Guillerey C, Nakamura K, Pichler AC, Barkauskas D, Krumeich S, Stannard K, Miles K, Harjunpää H, Yu Y, Casey M, Doban AI, Lazar M, Hartel G, Smith D, Vuckovic S, Teng MW, Bergsagel PL, Chesi M, Hill GR, Martinet L, Smyth MJ. Guillerey C, et al. Among authors: miles k. JCI Insight. 2019 Jun 13;5(14):e125932. doi: 10.1172/jci.insight.125932. JCI Insight. 2019. PMID: 31194697 Free PMC article.
Granzyme M has a critical role in providing innate immune protection in ulcerative colitis.
Souza-Fonseca-Guimaraes F, Krasnova Y, Putoczki T, Miles K, MacDonald KP, Town L, Shi W, Gobe GC, McDade L, Mielke LA, Tye H, Masters SL, Belz GT, Huntington ND, Radford-Smith G, Smyth MJ. Souza-Fonseca-Guimaraes F, et al. Among authors: miles k. Cell Death Dis. 2016 Jul 21;7(7):e2302. doi: 10.1038/cddis.2016.215. Cell Death Dis. 2016. PMID: 27441655 Free PMC article.
Immunosurveillance and therapy of multiple myeloma are CD226 dependent.
Guillerey C, Ferrari de Andrade L, Vuckovic S, Miles K, Ngiow SF, Yong MC, Teng MW, Colonna M, Ritchie DS, Chesi M, Bergsagel PL, Hill GR, Smyth MJ, Martinet L. Guillerey C, et al. Among authors: miles k. J Clin Invest. 2015 May;125(5):2077-89. doi: 10.1172/JCI77181. Epub 2015 Apr 20. J Clin Invest. 2015. PMID: 25893601 Free PMC article.
481 results