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DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis.
Beck MA, Fischer H, Grabner LM, Groffics T, Winter M, Tangermann S, Meischel T, Zaussinger-Haas B, Wagner P, Fischer C, Folie C, Arand J, Schöfer C, Ramsahoye B, Lagger S, Machat G, Eisenwort G, Schneider S, Podhornik A, Kothmayer M, Reichart U, Glösmann M, Tamir I, Mildner M, Sheibani-Tezerji R, Kenner L, Petzelbauer P, Egger G, Sibilia M, Ablasser A, Seiser C. Beck MA, et al. Among authors: mildner m. EMBO J. 2021 Nov 15;40(22):e108234. doi: 10.15252/embj.2021108234. Epub 2021 Sep 29. EMBO J. 2021. PMID: 34586646 Free PMC article.
DNase1L2 degrades nuclear DNA during corneocyte formation.
Fischer H, Eckhart L, Mildner M, Jaeger K, Buchberger M, Ghannadan M, Tschachler E. Fischer H, et al. Among authors: mildner m. J Invest Dermatol. 2007 Jan;127(1):24-30. doi: 10.1038/sj.jid.5700503. Epub 2006 Aug 10. J Invest Dermatol. 2007. PMID: 16902420 Free article.
DNase 2 is the main DNA-degrading enzyme of the stratum corneum.
Fischer H, Scherz J, Szabo S, Mildner M, Benarafa C, Torriglia A, Tschachler E, Eckhart L. Fischer H, et al. Among authors: mildner m. PLoS One. 2011 Mar 1;6(3):e17581. doi: 10.1371/journal.pone.0017581. PLoS One. 2011. PMID: 21390259 Free PMC article.
Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination.
Reinisch CM, Mildner M, Petzelbauer P, Pammer J. Reinisch CM, et al. Among authors: mildner m. Int J Exp Pathol. 2011 Oct;92(5):326-32. doi: 10.1111/j.1365-2613.2011.00769.x. Epub 2011 Mar 29. Int J Exp Pathol. 2011. PMID: 21446939 Free PMC article.
Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation.
Stremnitzer C, Manzano-Szalai K, Willensdorfer A, Starkl P, Pieper M, König P, Mildner M, Tschachler E, Reichart U, Jensen-Jarolim E. Stremnitzer C, et al. Among authors: mildner m. J Invest Dermatol. 2015 Jul;135(7):1790-1800. doi: 10.1038/jid.2015.58. Epub 2015 Feb 23. J Invest Dermatol. 2015. PMID: 25705851 Free PMC article.
164 results