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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
Sonveaux P, Copetti T, De Saedeleer CJ, Végran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frérart F, Gallez B, Ribeiro A, Michiels C, Dewhirst MW, Feron O. Sonveaux P, et al. Among authors: michiels c. PLoS One. 2012;7(3):e33418. doi: 10.1371/journal.pone.0033418. Epub 2012 Mar 13. PLoS One. 2012. PMID: 22428047 Free PMC article.
A mitochondrial switch promotes tumor metastasis.
Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. Porporato PE, et al. Among authors: michiels c. Cell Rep. 2014 Aug 7;8(3):754-66. doi: 10.1016/j.celrep.2014.06.043. Epub 2014 Jul 24. Cell Rep. 2014. PMID: 25066121 Free article.
531 results