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A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis.
EMBO Mol Med. 2022 Mar 7;14(3):e14552. doi: 10.15252/emmm.202114552. Epub 2022 Feb 17.
EMBO Mol Med. 2022.
PMID: 35174975
Free PMC article.
Animal models of brain metastasis.
Miarka L, Valiente M.
Miarka L, et al.
Neurooncol Adv. 2021 Nov 27;3(Suppl 5):v144-v156. doi: 10.1093/noajnl/vdab115. eCollection 2021 Nov.
Neurooncol Adv. 2021.
PMID: 34859241
Free PMC article.
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Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism.
Monteiro C, Miarka L, Perea-García M, Priego N, García-Gómez P, Álvaro-Espinosa L, de Pablos-Aragoneses A, Yebra N, Retana D, Baena P, Fustero-Torre C, Graña-Castro O, Troulé K, Caleiras E, Tezanos P, Muela P, Cintado E, Trejo JL, Sepúlveda JM, González-León P, Jiménez-Roldán L, Moreno LM, Esteban O, Pérez-Núñez Á, Hernández-Lain A, Mazarico Gallego J, Ferrer I, Suárez R, Garrido-Martín EM, Paz-Ares L, Dalmasso C, Cohen-Jonathan Moyal E, Siegfried A, Hegarty A, Keelan S, Varešlija D, Young LS, Mohme M, Goy Y, Wikman H, Fernández-Alén J, Blasco G, Alcázar L, Cabañuz C, Grivennikov SI, Ianus A, Shemesh N, Faria CC, Lee R, Lorigan P, Le Rhun E, Weller M, Soffietti R, Bertero L, Ricardi U, Bosch-Barrera J, Sais E, Teixidor E, Hernández-Martínez A, Calvo A, Aristu J, Martin SM, Gonzalez A, Adler O, Erez N; RENACER; Valiente M.
Monteiro C, et al. Among authors: miarka l.
Nat Med. 2022 Apr;28(4):752-765. doi: 10.1038/s41591-022-01749-8. Epub 2022 Apr 11.
Nat Med. 2022.
PMID: 35411077
Free PMC article.
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Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells.
Fabian A, Stegner S, Miarka L, Zimmermann J, Lenk L, Rahn S, Buttlar J, Viol F, Knaack H, Esser D, Schäuble S, Großmann P, Marinos G, Häsler R, Mikulits W, Saur D, Kaleta C, Schäfer H, Sebens S.
Fabian A, et al. Among authors: miarka l.
Cancer Lett. 2019 Jul 1;453:95-106. doi: 10.1016/j.canlet.2019.03.039. Epub 2019 Mar 28.
Cancer Lett. 2019.
PMID: 30930235
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Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells.
Knaack H, Lenk L, Philipp LM, Miarka L, Rahn S, Viol F, Hauser C, Egberts JH, Gundlach JP, Will O, Tiwari S, Mikulits W, Schumacher U, Hengstler JG, Sebens S.
Knaack H, et al. Among authors: miarka l.
Oncotarget. 2018 Aug 3;9(60):31771-31786. doi: 10.18632/oncotarget.25884. eCollection 2018 Aug 3.
Oncotarget. 2018.
PMID: 30167093
Free PMC article.
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Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy.
Zhu L, Miarka L, Baena P, Perea-García M, Valiente M.
Zhu L, et al. Among authors: miarka l.
STAR Protoc. 2023 Apr 8;4(2):102194. doi: 10.1016/j.xpro.2023.102194. Online ahead of print.
STAR Protoc. 2023.
PMID: 37031412
Free PMC article.
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The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection.
Miarka L, Hauser C, Helm O, Holdhof D, Beckinger S, Egberts JH, Gundlach JP, Lenk L, Rahn S, Mikulits W, Trauzold A, Sebens S.
Miarka L, et al.
Cancers (Basel). 2019 May 29;11(6):745. doi: 10.3390/cancers11060745.
Cancers (Basel). 2019.
PMID: 31146405
Free PMC article.
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