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Identification of formaldehyde-induced modifications in proteins: reactions with insulin.
Metz B, Kersten GF, Baart GJ, de Jong A, Meiring H, ten Hove J, van Steenbergen MJ, Hennink WE, Crommelin DJ, Jiskoot W. Metz B, et al. Bioconjug Chem. 2006 May-Jun;17(3):815-22. doi: 10.1021/bc050340f. Bioconjug Chem. 2006. PMID: 16704222
Both the location and the chemical nature of the modifications could be assigned based on the mass increase of potential adducts as elucidated in our previous study (B. Metz et al. (2004) J. Biol. Chem. 279, 6235-6243). To confirm the assigned structures, LC-MS meas …
Both the location and the chemical nature of the modifications could be assigned based on the mass increase of potential adducts as elucidat …
The potential of physicochemical and immunochemical assays to replace animal tests in the quality control of toxoid vaccines. The report and recommendations of ECVAM workshop 61.
Metz B, Brunel F, Chamberlin C, van der Gun J, Halder M, Jiskoot W, Kersten G, van Opstal O, Petersen JW, Ravetkar SD, Redhead K, Schwanig M, Wilhelmsen ES, Vann WF, Hendriksen C. Metz B, et al. Altern Lab Anim. 2007 Jun;35(3):323-31. doi: 10.1177/026119290703500307. Altern Lab Anim. 2007. PMID: 17650951 No abstract available.
Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques.
Metz B, Jiskoot W, Mekkes D, Kingma R, Hennink WE, Crommelin DJ, Kersten GF. Metz B, et al. Vaccine. 2007 Sep 28;25(39-40):6863-71. doi: 10.1016/j.vaccine.2007.07.009. Epub 2007 Jul 27. Vaccine. 2007. PMID: 17707558
Physicochemical and immunochemical techniques can be used to assess the quality of diphtheria toxoid vaccines. In a previous paper [Metz B, Jiskoot W, Hennink WE, Crommelin DJA, Kersten GFA. Physicochemical and immunochemical techniques predict the quality of diphth …
Physicochemical and immunochemical techniques can be used to assess the quality of diphtheria toxoid vaccines. In a previous paper [Metz …
Quality-control issues and approaches in vaccine development.
Metz B, van den Dobbelsteen G, van Els C, van der Gun J, Levels L, van der Pol L, Rots N, Kersten G. Metz B, et al. Expert Rev Vaccines. 2009 Feb;8(2):227-38. doi: 10.1586/14760584.8.2.227. Expert Rev Vaccines. 2009. PMID: 19196202 Review.
209 results