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Clostridioides difficile canonical L,D-transpeptidases catalyze a novel type of peptidoglycan cross-links and are not required for beta-lactam resistance.
Galley NF, Greetham D, Alamán-Zárate MG, Williamson MP, Evans CA, Spittal WD, Buddle JE, Freeman J, Davis GL, Dickman MJ, Wilcox MH, Lovering AL, Fagan RP, Mesnage S. Galley NF, et al. Among authors: mesnage s. J Biol Chem. 2024 Jan;300(1):105529. doi: 10.1016/j.jbc.2023.105529. Epub 2023 Dec 1. J Biol Chem. 2024. PMID: 38043796 Free PMC article.
Unusual 1-3 peptidoglycan cross-links in Acetobacteraceae are made by L,D-transpeptidases with a catalytic domain distantly related to YkuD domains.
Alamán-Zárate MG, Rady BJ, Evans CA, Pian B, Greetham D, Marecos-Ortiz S, Dickman MJ, Lidbury IDEA, Lovering AL, Barstow BM, Mesnage S. Alamán-Zárate MG, et al. Among authors: mesnage s. J Biol Chem. 2024 Jan;300(1):105494. doi: 10.1016/j.jbc.2023.105494. Epub 2023 Nov 23. J Biol Chem. 2024. PMID: 38006948 Free PMC article.
68 results