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HDAC3 functions as a positive regulator in Notch signal transduction.
Ferrante F, Giaimo BD, Bartkuhn M, Zimmermann T, Close V, Mertens D, Nist A, Stiewe T, Meier-Soelch J, Kracht M, Just S, Klöble P, Oswald F, Borggrefe T. Ferrante F, et al. Among authors: mertens d. Nucleic Acids Res. 2020 Apr 17;48(7):3496-3512. doi: 10.1093/nar/gkaa088. Nucleic Acids Res. 2020. PMID: 32107550 Free PMC article.
Missing the notch in NOTCH1.
Kugler SJ, Schnaiter A, Stilgenbauer S, Mertens D. Kugler SJ, et al. Among authors: mertens d. Leuk Lymphoma. 2013 Aug;54(8):1579-80. doi: 10.3109/10428194.2013.767459. Epub 2013 Feb 16. Leuk Lymphoma. 2013. PMID: 23323947 No abstract available.
Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.
Yosifov DY, Idler I, Bhattacharya N, Reichenzeller M, Close V, Ezerina D, Scheffold A, Jebaraj BMC, Kugler S, Bloehdorn J, Bahlo J, Robrecht S, Eichhorst B, Fischer K, Weigel A, Busch H, Lichter P, Döhner H, Dick TP, Stilgenbauer S, Mertens D. Yosifov DY, et al. Among authors: mertens d. Leukemia. 2020 Jan;34(1):115-127. doi: 10.1038/s41375-019-0513-x. Epub 2019 Jul 12. Leukemia. 2020. PMID: 31300746
Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.
Ferrante F, Giaimo BD, Friedrich T, Sugino T, Mertens D, Kugler S, Gahr BM, Just S, Pan L, Bartkuhn M, Potente M, Oswald F, Borggrefe T. Ferrante F, et al. Among authors: mertens d. Cell Death Dis. 2022 Jul 12;13(7):600. doi: 10.1038/s41419-022-05052-9. Cell Death Dis. 2022. PMID: 35821235 Free PMC article.
A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia.
Loeder S, Zenz T, Schnaiter A, Mertens D, Winkler D, Döhner H, Debatin KM, Stilgenbauer S, Fulda S. Loeder S, et al. Among authors: mertens d. Cancer Res. 2009 Dec 1;69(23):8977-86. doi: 10.1158/0008-5472.CAN-09-2604. Epub 2009 Nov 17. Cancer Res. 2009. PMID: 19920200
NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG.
Schnaiter A, Paschka P, Rossi M, Zenz T, Bühler A, Winkler D, Cazzola M, Döhner K, Edelmann J, Mertens D, Kless S, Mack S, Busch R, Hallek M, Döhner H, Stilgenbauer S. Schnaiter A, et al. Among authors: mertens d. Blood. 2013 Aug 15;122(7):1266-70. doi: 10.1182/blood-2013-03-488197. Epub 2013 Jul 2. Blood. 2013. PMID: 23821658 Free article. Clinical Trial.
NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib.
Wolf C, Garding A, Filarsky K, Bahlo J, Robrecht S, Becker N, Zucknick M, Rouhi A, Weigel A, Claus R, Weichenhan D, Eichhorst B, Fischer K, Hallek M, Kuchenbauer F, Plass C, Döhner H, Stilgenbauer S, Lichter P, Mertens D. Wolf C, et al. Among authors: mertens d. Int J Cancer. 2018 Jan 15;142(2):322-333. doi: 10.1002/ijc.31057. Epub 2017 Oct 9. Int J Cancer. 2018. PMID: 28921505 Free article.
Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.
Edelmann J, Holzmann K, Tausch E, Saunderson EA, Jebaraj BMC, Steinbrecher D, Dolnik A, Blätte TJ, Landau DA, Saub J, Estenfelder S, Ibach S, Cymbalista F, Leblond V, Delmer A, Bahlo J, Robrecht S, Fischer K, Goede V, Bullinger L, Wu CJ, Mertens D, Ficz G, Gribben JG, Hallek M, Döhner H, Stilgenbauer S. Edelmann J, et al. Among authors: mertens d. Haematologica. 2020 May;105(5):1379-1390. doi: 10.3324/haematol.2019.217307. Epub 2019 Aug 29. Haematologica. 2020. PMID: 31467127 Free PMC article. Clinical Trial.
265 results