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Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions.
Tai YH, Engels D, Locatelli G, Emmanouilidis I, Fecher C, Theodorou D, Müller SA, Licht-Mayer S, Kreutzfeldt M, Wagner I, de Mello NP, Gkotzamani SN, Trovò L, Kendirli A, Aljović A, Breckwoldt MO, Naumann R, Bareyre FM, Perocchi F, Mahad D, Merkler D, Lichtenthaler SF, Kerschensteiner M, Misgeld T. Tai YH, et al. Among authors: merkler d. Nat Metab. 2023 Aug;5(8):1364-1381. doi: 10.1038/s42255-023-00838-3. Epub 2023 Jul 10. Nat Metab. 2023. PMID: 37430025 Free PMC article.
Targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis.
Kerschensteiner M, Stadelmann C, Buddeberg BS, Merkler D, Bareyre FM, Anthony DC, Linington C, Brück W, Schwab ME. Kerschensteiner M, et al. Among authors: merkler d. Am J Pathol. 2004 Apr;164(4):1455-69. doi: 10.1016/S0002-9440(10)63232-4. Am J Pathol. 2004. PMID: 15039233 Free PMC article.
Targeted ablation of oligodendrocytes triggers axonal damage.
Ghosh A, Manrique-Hoyos N, Voigt A, Schulz JB, Kreutzfeldt M, Merkler D, Simons M. Ghosh A, et al. Among authors: merkler d. PLoS One. 2011;6(7):e22735. doi: 10.1371/journal.pone.0022735. Epub 2011 Jul 27. PLoS One. 2011. PMID: 21818378 Free PMC article.
Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.
Kreutzfeldt M, Bergthaler A, Fernandez M, Brück W, Steinbach K, Vorm M, Coras R, Blümcke I, Bonilla WV, Fleige A, Forman R, Müller W, Becher B, Misgeld T, Kerschensteiner M, Pinschewer DD, Merkler D. Kreutzfeldt M, et al. Among authors: merkler d. J Exp Med. 2013 Sep 23;210(10):2087-103. doi: 10.1084/jem.20122143. Epub 2013 Sep 2. J Exp Med. 2013. PMID: 23999498 Free PMC article.
253 results