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Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins.
García-Arriaza J, Marín MQ, Merchán-Rubira J, Mascaraque SM, Medina M, Ávila J, Hernández F, Esteban M. García-Arriaza J, et al. Among authors: merchan rubira j. Vaccines (Basel). 2020 Mar 13;8(1):127. doi: 10.3390/vaccines8010127. Vaccines (Basel). 2020. PMID: 32183198 Free PMC article.
Tau-positive nuclear indentations in P301S tauopathy mice.
Fernández-Nogales M, Santos-Galindo M, Merchán-Rubira J, Hoozemans JJM, Rábano A, Ferrer I, Avila J, Hernández F, Lucas JJ. Fernández-Nogales M, et al. Among authors: merchan rubira j. Brain Pathol. 2017 May;27(3):314-322. doi: 10.1111/bpa.12407. Epub 2016 Aug 2. Brain Pathol. 2017. PMID: 27338164 Free PMC article.
MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus.
Beamer EH, Jurado-Arjona J, Jimenez-Mateos EM, Morgan J, Reschke CR, Kenny A, de Leo G, Olivos-Oré LA, Arribas-Blázquez M, Madden SF, Merchán-Rubira J, Delanty N, Farrell MA, O'Brien DF, Avila J, Diaz-Hernandez M, Miras-Portugal MT, Artalejo AR, Hernandez F, Henshall DC, Engel T. Beamer EH, et al. Among authors: merchan rubira j. Front Mol Neurosci. 2018 Dec 11;11:442. doi: 10.3389/fnmol.2018.00442. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30618601 Free PMC article.
Differences Between Human and Murine Tau at the N-terminal End.
Hernández F, Merchán-Rubira J, Vallés-Saiz L, Rodríguez-Matellán A, Avila J. Hernández F, et al. Among authors: merchan rubira j. Front Aging Neurosci. 2020 Jan 28;12:11. doi: 10.3389/fnagi.2020.00011. eCollection 2020. Front Aging Neurosci. 2020. PMID: 32063841 Free PMC article. Review.
Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration.
Galán-Ganga M, Rodríguez-Cueto C, Merchán-Rubira J, Hernández F, Ávila J, Posada-Ayala M, Lanciego JL, Luengo E, Lopez MG, Rábano A, Fernández-Ruiz J, Lastres-Becker I. Galán-Ganga M, et al. Among authors: merchan rubira j. Acta Neuropathol Commun. 2021 May 17;9(1):90. doi: 10.1186/s40478-021-01196-5. Acta Neuropathol Commun. 2021. PMID: 34001284 Free PMC article.
TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy.
Sebastián-Serrano Á, Merchán-Rubira J, Di Lauro C, Bianchi C, Soria-Tobar L, Narisawa S, Millán JL, Ávila J, Hernández F, Díaz-Hernández M. Sebastián-Serrano Á, et al. Among authors: merchan rubira j. Neurobiol Dis. 2022 Apr;165:105632. doi: 10.1016/j.nbd.2022.105632. Epub 2022 Jan 19. Neurobiol Dis. 2022. PMID: 35065251 Free article.