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The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.
Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ. Pekovic-Vaughan V, et al. Among authors: meng qj. Genes Dev. 2014 Mar 15;28(6):548-60. doi: 10.1101/gad.237081.113. Genes Dev. 2014. PMID: 24637114 Free PMC article.
The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration.
Dudek M, Yang N, Ruckshanthi JP, Williams J, Borysiewicz E, Wang P, Adamson A, Li J, Bateman JF, White MR, Boot-Handford RP, Hoyland JA, Meng QJ. Dudek M, et al. Among authors: meng qj. Ann Rheum Dis. 2017 Mar;76(3):576-584. doi: 10.1136/annrheumdis-2016-209428. Epub 2016 Aug 3. Ann Rheum Dis. 2017. PMID: 27489225 Free PMC article.
Circadian clocks and breast cancer.
Blakeman V, Williams JL, Meng QJ, Streuli CH. Blakeman V, et al. Among authors: meng qj. Breast Cancer Res. 2016 Sep 2;18(1):89. doi: 10.1186/s13058-016-0743-z. Breast Cancer Res. 2016. PMID: 27590298 Free PMC article. Review.
Cellular mechano-environment regulates the mammary circadian clock.
Yang N, Williams J, Pekovic-Vaughan V, Wang P, Olabi S, McConnell J, Gossan N, Hughes A, Cheung J, Streuli CH, Meng QJ. Yang N, et al. Among authors: meng qj. Nat Commun. 2017 Jan 30;8:14287. doi: 10.1038/ncomms14287. Nat Commun. 2017. PMID: 28134247 Free PMC article.
Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.
Yang N, Smyllie NJ, Morris H, Gonçalves CF, Dudek M, Pathiranage DRJ, Chesham JE, Adamson A, Spiller DG, Zindy E, Bagnall J, Humphreys N, Hoyland J, Loudon ASI, Hastings MH, Meng QJ. Yang N, et al. Among authors: meng qj. PLoS Genet. 2020 Apr 30;16(4):e1008729. doi: 10.1371/journal.pgen.1008729. eCollection 2020 Apr. PLoS Genet. 2020. PMID: 32352975 Free PMC article.
118 results