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Modular, stereocontrolled Cβ-H/Cα-C activation of alkyl carboxylic acids.
Shang M, Feu KS, Vantourout JC, Barton LM, Osswald HL, Kato N, Gagaring K, McNamara CW, Chen G, Hu L, Ni S, Fernández-Canelas P, Chen M, Merchant RR, Qin T, Schreiber SL, Melillo B, Yu JQ, Baran PS. Shang M, et al. Among authors: melillo b. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8721-8727. doi: 10.1073/pnas.1903048116. Epub 2019 Apr 17. Proc Natl Acad Sci U S A. 2019. PMID: 30996125 Free PMC article.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, Lazear MR, Yin S, Blewett MM, Dix MM, Nguyen N, Shokhirev MN, Chin EN, Lairson LL, Melillo B, Schreiber SL, Forli S, Teijaro JR, Cravatt BF. Vinogradova EV, et al. Among authors: melillo b. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29. Cell. 2020. PMID: 32730809 Free PMC article.
Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase.
Vinayak S, Jumani RS, Miller P, Hasan MM, McLeod BI, Tandel J, Stebbins EE, Teixeira JE, Borrel J, Gonse A, Zhang M, Yu X, Wernimont A, Walpole C, Eckley S, Love MS, McNamara CW, Sharma M, Sharma A, Scherer CA, Kato N, Schreiber SL, Melillo B, Striepen B, Huston CD, Comer E. Vinayak S, et al. Among authors: melillo b. Sci Transl Med. 2020 Sep 30;12(563):eaba8412. doi: 10.1126/scitranslmed.aba8412. Sci Transl Med. 2020. PMID: 32998973 Free PMC article.
54 results