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Rotaxanating Metallo-supramolecular Nano-cylinder Helicates to Switch DNA Junction Binding.
Hooper CAJ, Cardo L, Craig JS, Melidis L, Garai A, Egan RT, Sadovnikova V, Burkert F, Male L, Hodges NJ, Browning DF, Rosas R, Liu F, Rocha FV, Lima MA, Liu S, Bardelang D, Hannon MJ. Hooper CAJ, et al. Among authors: melidis l. J Am Chem Soc. 2020 Dec 9;142(49):20651-20660. doi: 10.1021/jacs.0c07750. Epub 2020 Nov 20. J Am Chem Soc. 2020. PMID: 33215921 Free article.
Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.
Melidis L, Hill HJ, Coltman NJ, Davies SP, Winczura K, Chauhan T, Craig JS, Garai A, Hooper CAJ, Egan RT, McKeating JA, Hodges NJ, Stamataki Z, Grzechnik P, Hannon MJ. Melidis L, et al. Angew Chem Int Ed Engl. 2021 Aug 9;60(33):18144-18151. doi: 10.1002/anie.202104179. Epub 2021 Jul 9. Angew Chem Int Ed Engl. 2021. PMID: 33915014 Free PMC article.
Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB.
Carnie CJ, Acampora AC, Bader AS, Erdenebat C, Zhao S, Bitensky E, van den Heuvel D, Parnas A, Gupta V, D'Alessandro G, Sczaniecka-Clift M, Weickert P, Aygenli F, Götz MJ, Cordes J, Esain-Garcia I, Melidis L, Wondergem AP, Lam S, Robles MS, Balasubramanian S, Adar S, Luijsterburg MS, Jackson SP, Stingele J. Carnie CJ, et al. Among authors: melidis l. Nat Cell Biol. 2024 Apr 10. doi: 10.1038/s41556-024-01391-1. Online ahead of print. Nat Cell Biol. 2024. PMID: 38600235
An Upstream G-Quadruplex DNA Structure Can Stimulate Gene Transcription.
Chen Y, Simeone A, Melidis L, Cuesta SM, Tannahill D, Balasubramanian S. Chen Y, et al. Among authors: melidis l. ACS Chem Biol. 2024 Mar 15;19(3):736-742. doi: 10.1021/acschembio.3c00775. Epub 2024 Feb 28. ACS Chem Biol. 2024. PMID: 38417105 Free PMC article.
G-quadruplex DNA structure is a positive regulator of MYC transcription.
Esain-Garcia I, Kirchner A, Melidis L, Tavares RCA, Dhir S, Simeone A, Yu Z, Madden SK, Hermann R, Tannahill D, Balasubramanian S. Esain-Garcia I, et al. Among authors: melidis l. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2320240121. doi: 10.1073/pnas.2320240121. Epub 2024 Feb 5. Proc Natl Acad Sci U S A. 2024. PMID: 38315865 Free PMC article.
Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks.
Craig JS, Melidis L, Williams HD, Dettmer SJ, Heidecker AA, Altmann PJ, Guan S, Campbell C, Browning DF, Sigel RKO, Johannsen S, Egan RT, Aikman B, Casini A, Pöthig A, Hannon MJ. Craig JS, et al. Among authors: melidis l. J Am Chem Soc. 2023 Jun 28;145(25):13570-13580. doi: 10.1021/jacs.3c00118. Epub 2023 Jun 15. J Am Chem Soc. 2023. PMID: 37318835 Free PMC article.
Chem-map profiles drug binding to chromatin in cells.
Yu Z, Spiegel J, Melidis L, Hui WWI, Zhang X, Radzevičius A, Balasubramanian S. Yu Z, et al. Among authors: melidis l. Nat Biotechnol. 2023 Sep;41(9):1265-1271. doi: 10.1038/s41587-022-01636-0. Epub 2023 Jan 23. Nat Biotechnol. 2023. PMID: 36690761 Free PMC article.
11 results