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Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death.
Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelman H, Slütter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen MJAP, Weber C, Gerdes N, de Winther MPJ, Lutgens E. Seijkens TTP, et al. Among authors: meiler s. Eur Heart J. 2019 Jan 21;40(4):372-382. doi: 10.1093/eurheartj/ehy714. Eur Heart J. 2019. PMID: 30452556 Free PMC article.
CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice.
Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Bürger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N. Winkels H, et al. Among authors: meiler s. Eur Heart J. 2017 Dec 21;38(48):3590-3599. doi: 10.1093/eurheartj/ehx517. Eur Heart J. 2017. PMID: 29045618
Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
Shami A, Atzler D, Bosmans LA, Winkels H, Meiler S, Lacy M, van Tiel C, Ta Megens R, Nitz K, Baardman J, Kusters P, Seijkens T, Buerger C, Janjic A, Riccardi C, Edsfeldt A, Monaco C, Daemen M, de Winther MPJ, Nilsson J, Weber C, Gerdes N, Gonçalves I, Lutgens E. Shami A, et al. Among authors: meiler s. Eur Heart J. 2020 Aug 14;41(31):2938-2948. doi: 10.1093/eurheartj/ehaa484. Eur Heart J. 2020. PMID: 32728688 Free PMC article.
CD70 limits atherosclerosis and promotes macrophage function.
Winkels H, Meiler S, Smeets E, Lievens D, Engel D, Spitz C, Bürger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RT, Schmitt M, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N. Winkels H, et al. Among authors: meiler s. Thromb Haemost. 2017 Jan 5;117(1):164-175. doi: 10.1160/TH16-04-0318. Epub 2016 Oct 27. Thromb Haemost. 2017. PMID: 27786334
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.
Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Hoeksema MA, et al. Among authors: meiler s. EMBO Mol Med. 2014 Sep;6(9):1124-32. doi: 10.15252/emmm.201404170. EMBO Mol Med. 2014. PMID: 25007801 Free PMC article.
Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis.
van der Valk FM, Schulte DM, Meiler S, Tang J, Zheng KH, Van den Bossche J, Seijkens T, Laudes M, de Winther M, Lutgens E, Alaarg A, Metselaar JM, Dallinga-Thie GM, Mulder WJ, Stroes ES, Hamers AA. van der Valk FM, et al. Among authors: meiler s. Nanomedicine. 2016 Aug;12(6):1463-70. doi: 10.1016/j.nano.2016.02.022. Epub 2016 Mar 23. Nanomedicine. 2016. PMID: 27015770
75 results