Medina-Carmona E - Search Results

1

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms.

Pey AL, Megarity CF, Medina-Carmona E, Timson DJ. Pey AL, et al. Curr Drug Targets. 2016;17(13):1506-14. doi: 10.2174/1389450117666160101121610. Curr Drug Targets. 2016. PMID: 26721407 Review.

2

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Medina-Carmona E, Palomino-Morales RJ, Fuchs JE, Padín-Gonzalez E, Mesa-Torres N, Salido E, Timson DJ, Pey AL. Medina-Carmona E, et al. Sci Rep. 2016 Feb 3;6:20331. doi: 10.1038/srep20331. Sci Rep. 2016. PMID: 26838129 Free PMC article.

3

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

Medina-Carmona E, Neira JL, Salido E, Fuchs JE, Palomino-Morales R, Timson DJ, Pey AL. Medina-Carmona E, et al. Sci Rep. 2017 Mar 14;7:44532. doi: 10.1038/srep44532. Sci Rep. 2017. PMID: 28291250 Free PMC article.

4

A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R.

Muñoz IG, Morel B, Medina-Carmona E, Pey AL. Muñoz IG, et al. FEBS Lett. 2017 Sep;591(18):2826-2835. doi: 10.1002/1873-3468.12772. Epub 2017 Aug 20. FEBS Lett. 2017. PMID: 28771686 Free article.

5

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.

Medina-Carmona E, Fuchs JE, Gavira JA, Mesa-Torres N, Neira JL, Salido E, Palomino-Morales R, Burgos M, Timson DJ, Pey AL. Medina-Carmona E, et al. Hum Mol Genet. 2017 Sep 15;26(18):3531-3544. doi: 10.1093/hmg/ddx238. Hum Mol Genet. 2017. PMID: 28911204

6

Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability.

Medina-Carmona E, Rizzuti B, Martín-Escolano R, Pacheco-García JL, Mesa-Torres N, Neira JL, Guzzi R, Pey AL. Medina-Carmona E, et al. Int J Biol Macromol. 2019 Mar 15;125:1275-1288. doi: 10.1016/j.ijbiomac.2018.09.108. Epub 2018 Sep 19. Int J Biol Macromol. 2019. PMID: 30243998

7

Erratum: Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.

Medina-Carmona E, Palomino-Morales RJ, Fuchs JE, Padín-Gonzalez E, Mesa-Torres N, Salido E, Timson DJ, Pey AL. Medina-Carmona E, et al. Sci Rep. 2016 Mar 4;6:21939. doi: 10.1038/srep21939. Sci Rep. 2016. PMID: 26942855 Free PMC article. No abstract available.

8

Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses.

Medina-Carmona E, Betancor-Fernández I, Santos J, Mesa-Torres N, Grottelli S, Batlle C, Naganathan AN, Oppici E, Cellini B, Ventura S, Salido E, Pey AL. Medina-Carmona E, et al. Hum Mol Genet. 2019 Jan 1;28(1):1-15. doi: 10.1093/hmg/ddy323. Hum Mol Genet. 2019. PMID: 30215702

9

Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi.

Martín-Escolano R, Moreno-Viguri E, Santivañez-Veliz M, Martin-Montes A, Medina-Carmona E, Paucar R, Marín C, Azqueta A, Cirauqui N, Pey AL, Pérez-Silanes S, Sánchez-Moreno M. Martín-Escolano R, et al. J Med Chem. 2018 Jul 12;61(13):5643-5663. doi: 10.1021/acs.jmedchem.8b00468. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29883536

10

The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase.

Neira JL, Medina-Carmona E, Hernández-Cifre JG, Montoliu-Gaya L, Cámara-Artigás A, Seffouh I, Gonnet F, Daniel R, Villegas S, de la Torre JG, Pey AL, Li F. Neira JL, et al. Biochimie. 2016 Dec;131:85-95. doi: 10.1016/j.biochi.2016.09.015. Epub 2016 Oct 1. Biochimie. 2016. PMID: 27687161

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