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Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat.
Nat Commun. 2024 Apr 12;15(1):3182. doi: 10.1038/s41467-024-47485-0.
Nat Commun. 2024.
PMID: 38609352
Free PMC article.
Posttranscriptional regulation of FAN1 by miR-124-3p at rs3512 underlies onset-delaying genetic modification in Huntington's disease.
Kim KH, Hong EP, Lee Y, McLean ZL, Elezi E, Lee R, Kwak S, McAllister B, Massey TH, Lobanov S, Holmans P, Orth M, Ciosi M, Monckton DG, Long JD, Lucente D, Wheeler VC, MacDonald ME, Gusella JF, Lee JM.
Kim KH, et al. Among authors: mclean zl.
Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2322924121. doi: 10.1073/pnas.2322924121. Epub 2024 Apr 12.
Proc Natl Acad Sci U S A. 2024.
PMID: 38607933
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PMS1 as a target for splice modulation to prevent somatic CAG repeat expansion in Huntington's disease.
McLean ZL, Gao D, Correia K, Roy JCL, Shibata S, Farnum IN, Valdepenas-Mellor Z, Rapuru M, Morini E, Ruliera J, Gillis T, Lucente D, Kleinstiver BP, Lee JM, MacDonald ME, Wheeler VC, Pinto RM, Gusella JF.
McLean ZL, et al.
bioRxiv [Preprint]. 2023 Jul 27:2023.07.25.550489. doi: 10.1101/2023.07.25.550489.
bioRxiv. 2023.
PMID: 37547003
Free PMC article.
Updated.
Preprint.
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Double cytoplast embryonic cloning improves in vitro but not in vivo development from mitotic pluripotent cells in cattle.
Appleby SJ, Misica-Turner P, Oback FC, Dhali A, McLean ZL, Oback B.
Appleby SJ, et al. Among authors: mclean zl.
Front Genet. 2022 Sep 28;13:933534. doi: 10.3389/fgene.2022.933534. eCollection 2022.
Front Genet. 2022.
PMID: 36246653
Free PMC article.
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Genetic modifiers of Huntington disease differentially influence motor and cognitive domains.
Lee JM, Huang Y, Orth M, Gillis T, Siciliano J, Hong E, Mysore JS, Lucente D, Wheeler VC, Seong IS, McLean ZL, Mills JA, McAllister B, Lobanov SV, Massey TH, Ciosi M, Landwehrmeyer GB, Paulsen JS, Dorsey ER, Shoulson I, Sampaio C, Monckton DG, Kwak S, Holmans P, Jones L, MacDonald ME, Long JD, Gusella JF.
Lee JM, et al. Among authors: mclean zl.
Am J Hum Genet. 2022 May 5;109(5):885-899. doi: 10.1016/j.ajhg.2022.03.004. Epub 2022 Mar 23.
Am J Hum Genet. 2022.
PMID: 35325614
Free PMC article.
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Controlled Cytoplast Arrest and Morula Aggregation Enhance Development, Cryoresilience, and In Vivo Survival of Cloned Sheep Embryos.
McLean ZL, Appleby SJ, Fermin LM, Henderson HV, Wei J, Wells DN, Oback B.
McLean ZL, et al.
Cell Reprogram. 2021 Feb;23(1):14-25. doi: 10.1089/cell.2020.0078.
Cell Reprogram. 2021.
PMID: 33529123
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Testes of DAZL null neonatal sheep lack prospermatogonia but maintain normal somatic cell morphology and marker expression.
McLean ZL, Appleby SJ, Wei J, Snell RG, Oback B.
McLean ZL, et al.
Mol Reprod Dev. 2021 Jan;88(1):3-14. doi: 10.1002/mrd.23443. Epub 2020 Nov 29.
Mol Reprod Dev. 2021.
PMID: 33251684
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