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A kinase-cGAS cascade to synthesize a therapeutic STING activator.
McIntosh JA, Liu Z, Andresen BM, Marzijarani NS, Moore JC, Marshall NM, Borra-Garske M, Obligacion JV, Fier PS, Peng F, Forstater JH, Winston MS, An C, Chang W, Lim J, Huffman MA, Miller SP, Tsay FR, Altman MD, Lesburg CA, Steinhuebel D, Trotter BW, Cumming JN, Northrup A, Bu X, Mann BF, Biba M, Hiraga K, Murphy GS, Kolev JN, Makarewicz A, Pan W, Farasat I, Bade RS, Stone K, Duan D, Alvizo O, Adpressa D, Guetschow E, Hoyt E, Regalado EL, Castro S, Rivera N, Smith JP, Wang F, Crespo A, Verma D, Axnanda S, Dance ZEX, Devine PN, Tschaen D, Canada KA, Bulger PG, Sherry BD, Truppo MD, Ruck RT, Campeau LC, Bennett DJ, Humphrey GR, Campos KR, Maddess ML. McIntosh JA, et al. Nature. 2022 Mar;603(7901):439-444. doi: 10.1038/s41586-022-04422-9. Epub 2022 Mar 16. Nature. 2022. PMID: 35296845
Deep Dive into Machine Learning Models for Protein Engineering.
Xu Y, Verma D, Sheridan RP, Liaw A, Ma J, Marshall NM, McIntosh J, Sherer EC, Svetnik V, Johnston JM. Xu Y, et al. J Chem Inf Model. 2020 Jun 22;60(6):2773-2790. doi: 10.1021/acs.jcim.0c00073. Epub 2020 May 5. J Chem Inf Model. 2020. PMID: 32250622
Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19.
McIntosh JA, Benkovics T, Silverman SM, Huffman MA, Kong J, Maligres PE, Itoh T, Yang H, Verma D, Pan W, Ho HI, Vroom J, Knight AM, Hurtak JA, Klapars A, Fryszkowska A, Morris WJ, Strotman NA, Murphy GS, Maloney KM, Fier PS. McIntosh JA, et al. ACS Cent Sci. 2021 Dec 22;7(12):1980-1985. doi: 10.1021/acscentsci.1c00608. Epub 2021 Oct 29. ACS Cent Sci. 2021. PMID: 34963891 Free PMC article.
Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454.
Benkovics T, Peng F, Phillips EM, An C, Bade RS, Chung CK, Dance ZEX, Fier PS, Forstater JH, Liu Z, Liu Z, Maligres PE, Marshall NM, Salehi Marzijarani N, McIntosh JA, Miller SP, Moore JC, Neel AJ, Obligacion JV, Pan W, Pirnot MT, Poirier M, Reibarkh M, Sherry BD, Song ZJ, Tan L, Turnbull BWH, Verma D, Waldman JH, Wang L, Wang T, Winston MS, Xu F. Benkovics T, et al. Among authors: mcintosh ja. J Am Chem Soc. 2022 Apr 6;144(13):5855-5863. doi: 10.1021/jacs.1c12106. Epub 2022 Mar 25. J Am Chem Soc. 2022. PMID: 35333525
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Cheung-Lee WL, Kolev JN, McIntosh JA, Gil AA, Pan W, Xiao L, Velásquez JE, Gangam R, Winston MS, Li S, Abe K, Alwedi E, Dance ZEX, Fan H, Hiraga K, Kim J, Kosjek B, Le DN, Marzijarani NS, Mattern K, McMullen JP, Narsimhan K, Vikram A, Wang W, Yan JX, Yang RS, Zhang V, Zhong W, DiRocco DA, Morris WJ, Murphy GS, Maloney KM. Cheung-Lee WL, et al. Among authors: mcintosh ja. Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202316133. doi: 10.1002/anie.202316133. Epub 2024 Feb 19. Angew Chem Int Ed Engl. 2024. PMID: 38279624
Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.
Hao Y, Pierce E, Roe D, Morita M, McIntosh JA, Agarwal V, Cheatham TE 3rd, Schmidt EW, Nair SK. Hao Y, et al. Among authors: mcintosh ja. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14037-14042. doi: 10.1073/pnas.1609869113. Epub 2016 Nov 21. Proc Natl Acad Sci U S A. 2016. PMID: 27872314 Free PMC article.
48 results