McFarland CD - Search Results

1

A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer.

Cai H, Chew SK, Li C, Tsai MK, Andrejka L, Murray CW, Hughes NW, Shuldiner EG, Ashkin EL, Tang R, Hung KL, Chen LC, Lee SYC, Yousefi M, Lin WY, Kunder CA, Cong L, McFarland CD, Petrov DA, Swanton C, Winslow MM. Cai H, et al. Among authors: mcfarland cd. Cancer Discov. 2021 Jul;11(7):1754-1773. doi: 10.1158/2159-8290.CD-20-1325. Epub 2021 Feb 19. Cancer Discov. 2021. PMID: 33608386 Free PMC article.

2

A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo.

Rogers ZN, McFarland CD, Winters IP, Naranjo S, Chuang CH, Petrov D, Winslow MM. Rogers ZN, et al. Among authors: mcfarland cd. Nat Methods. 2017 Jul;14(7):737-742. doi: 10.1038/nmeth.4297. Epub 2017 May 22. Nat Methods. 2017. PMID: 28530655 Free PMC article.

3

Quantitative In Vivo Analyses Reveal a Complex Pharmacogenomic Landscape in Lung Adenocarcinoma.

Li C, Lin WY, Rizvi H, Cai H, McFarland CD, Rogers ZN, Yousefi M, Winters IP, Rudin CM, Petrov DA, Winslow MM. Li C, et al. Among authors: mcfarland cd. Cancer Res. 2021 Sep 1;81(17):4570-4580. doi: 10.1158/0008-5472.CAN-21-0716. Epub 2021 Jul 2. Cancer Res. 2021. PMID: 34215621 Free PMC article.

4

Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice.

Rogers ZN, McFarland CD, Winters IP, Seoane JA, Brady JJ, Yoon S, Curtis C, Petrov DA, Winslow MM. Rogers ZN, et al. Among authors: mcfarland cd. Nat Genet. 2018 Apr;50(4):483-486. doi: 10.1038/s41588-018-0083-2. Epub 2018 Apr 2. Nat Genet. 2018. PMID: 29610476 Free PMC article.

5

Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity.

Winters IP, Chiou SH, Paulk NK, McFarland CD, Lalgudi PV, Ma RK, Lisowski L, Connolly AJ, Petrov DA, Kay MA, Winslow MM. Winters IP, et al. Among authors: mcfarland cd. Nat Commun. 2017 Dec 12;8(1):2053. doi: 10.1038/s41467-017-01519-y. Nat Commun. 2017. PMID: 29233960 Free PMC article.

6

Most cancers carry a substantial deleterious load due to Hill-Robertson interference.

Tilk S, Tkachenko S, Curtis C, Petrov DA, McFarland CD. Tilk S, et al. Among authors: mcfarland cd. Elife. 2022 Sep 1;11:e67790. doi: 10.7554/eLife.67790. Elife. 2022. PMID: 36047771 Free PMC article.

7

An in vivo multiplexed small-molecule screening platform.

Grüner BM, Schulze CJ, Yang D, Ogasawara D, Dix MM, Rogers ZN, Chuang CH, McFarland CD, Chiou SH, Brown JM, Cravatt BF, Bogyo M, Winslow MM. Grüner BM, et al. Among authors: mcfarland cd. Nat Methods. 2016 Oct;13(10):883-889. doi: 10.1038/nmeth.3992. Epub 2016 Sep 12. Nat Methods. 2016. PMID: 27617390 Free PMC article.

8

The Damaging Effect of Passenger Mutations on Cancer Progression.

McFarland CD, Yaglom JA, Wojtkowiak JW, Scott JG, Morse DL, Sherman MY, Mirny LA. McFarland CD, et al. Cancer Res. 2017 Sep 15;77(18):4763-4772. doi: 10.1158/0008-5472.CAN-15-3283-T. Epub 2017 May 23. Cancer Res. 2017. PMID: 28536279 Free PMC article.

9

Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer.

Yaglom JA, McFarland C, Mirny L, Sherman MY. Yaglom JA, et al. Oncotarget. 2014 Sep 30;5(18):8367-78. doi: 10.18632/oncotarget.2259. Oncotarget. 2014. PMID: 25252808 Free PMC article.

10

Tug-of-war between driver and passenger mutations in cancer and other adaptive processes.

McFarland CD, Mirny LA, Korolev KS. McFarland CD, et al. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15138-43. doi: 10.1073/pnas.1404341111. Epub 2014 Oct 2. Proc Natl Acad Sci U S A. 2014. PMID: 25277973 Free PMC article.

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