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Nanoencapsulation of MDM2 Inhibitor RG7388 and Class-I HDAC Inhibitor Entinostat Enhances their Therapeutic Potential Through Synergistic Antitumor Effects and Reduction of Systemic Toxicity.
Abed A, Greene MK, Alsa'd AA, Lees A, Hindley A, Longley DB, McDade SS, Scott CJ. Abed A, et al. Among authors: mcdade ss. Mol Pharm. 2024 Mar 4;21(3):1246-1255. doi: 10.1021/acs.molpharmaceut.3c00926. Epub 2024 Feb 9. Mol Pharm. 2024. PMID: 38334409 Free PMC article.
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Crawford N, Stott KJ, Sessler T, McCann C, McDaid W, Lees A, Latimer C, Fox JP, Munck JM, Smyth T, Shah A, Martins V, Lawler M, Dunne PD, Kerr EM, McDade SS, Coyle VM, Longley DB. Crawford N, et al. Among authors: mcdade ss. Mol Cancer Ther. 2021 Sep;20(9):1627-1639. doi: 10.1158/1535-7163.MCT-20-1050. Epub 2021 Aug 13. Mol Cancer Ther. 2021. PMID: 34389694 Free PMC article.
The pseudo-caspase FLIP(L) regulates cell fate following p53 activation.
Lees A, McIntyre AJ, Crawford NT, Falcone F, McCann C, Holohan C, Quinn GP, Roberts JZ, Sessler T, Gallagher PF, Gregg GMA, McAllister K, McLaughlin KM, Allen WL, Egan LJ, Ryan AE, Labonte-Wilson MJ, Dunne PD, Wappett M, Coyle VM, Johnston PG, Kerr EM, Longley DB, McDade SS. Lees A, et al. Among authors: mcdade ss. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17808-17819. doi: 10.1073/pnas.2001520117. Epub 2020 Jul 13. Proc Natl Acad Sci U S A. 2020. PMID: 32661168 Free PMC article.
Dying to Survive-The p53 Paradox.
Lees A, Sessler T, McDade S. Lees A, et al. Cancers (Basel). 2021 Jun 29;13(13):3257. doi: 10.3390/cancers13133257. Cancers (Basel). 2021. PMID: 34209840 Free PMC article. Review.
Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists.
Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, McAllister K, Prehn J, Young J, Bateson J, Gallagher L, Michaut M, Iyer V, Chatzipli A, Barthorpe S, Ciznadija D, Sloma I, Wesa A, Tice DA, Wessels L, Garnett M, Longley DB, McDermott U, McDade SS. Grinkevitch V, et al. Among authors: mcdade ss. Mol Cancer Ther. 2022 Apr 1;21(4):594-606. doi: 10.1158/1535-7163.MCT-21-0532. Mol Cancer Ther. 2022. PMID: 35086954 Free PMC article.
Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer.
Khawaja H, Briggs R, Latimer CH, Rassel M, Griffin D, Hanson L, Bardelli A, Di Nicolantonio F, McDade SS, Scott CJ, Lambe S, Maurya M, Lindner AU, Prehn JHM, Sousa J, Winnington C, LaBonte MJ, Ross S, Van Schaeybroeck S. Khawaja H, et al. Among authors: mcdade ss. Mol Cancer Ther. 2023 Jan 3;22(1):135-149. doi: 10.1158/1535-7163.MCT-22-0301. Mol Cancer Ther. 2023. PMID: 36279564 Free PMC article.
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