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A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity.
García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, Brea J, Loza MI, Alén F, Botta J, McCormick PJ, Ballesteros JA, Benhamú B, Rodríguez de Fonseca F, López-Rodríguez ML. García-Cárceles J, et al. Among authors: mccormick pj. J Med Chem. 2017 Dec 14;60(23):9575-9584. doi: 10.1021/acs.jmedchem.7b00994. Epub 2017 Nov 17. J Med Chem. 2017. PMID: 29116785
A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.
González-Vera JA, Medina RA, Martín-Fontecha M, Gonzalez A, de la Fuente T, Vázquez-Villa H, García-Cárceles J, Botta J, McCormick PJ, Benhamú B, Pardo L, López-Rodríguez ML. González-Vera JA, et al. Among authors: mccormick pj. Sci Rep. 2017 Jan 24;7:41293. doi: 10.1038/srep41293. Sci Rep. 2017. PMID: 28117458 Free PMC article.
Continuing challenges in targeting oligomeric GPCR-based drugs.
Botta J, Appelhans J, McCormick PJ. Botta J, et al. Among authors: mccormick pj. Prog Mol Biol Transl Sci. 2020;169:213-245. doi: 10.1016/bs.pmbts.2019.11.009. Epub 2020 Jan 3. Prog Mol Biol Transl Sci. 2020. PMID: 31952687 Review.
Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.
Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B. Busnelli M, et al. Among authors: mccormick pj. J Med Chem. 2016 Aug 11;59(15):7152-66. doi: 10.1021/acs.jmedchem.6b00564. Epub 2016 Jul 28. J Med Chem. 2016. PMID: 27420737 Free article.
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.
Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell LA, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M. Moreno E, et al. Among authors: mccormick pj. Neuropsychopharmacology. 2018 Apr;43(5):964-977. doi: 10.1038/npp.2017.12. Epub 2017 Jan 19. Neuropsychopharmacology. 2018. PMID: 28102227 Free PMC article.
Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease.
Moreno-Delgado D, Puigdellívol M, Moreno E, Rodríguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA, Scarselli M, Casadó V, Cortés A, Ferré S, Guzmán M, Lluís C, Alberch J, Canela EI, Ginés S, McCormick PJ. Moreno-Delgado D, et al. Among authors: mccormick pj. Elife. 2020 Jun 9;9:e51093. doi: 10.7554/eLife.51093. Elife. 2020. PMID: 32513388 Free PMC article.
Identification of BiP as a CB1 Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain.
Costas-Insua C, Moreno E, Maroto IB, Ruiz-Calvo A, Bajo-Grañeras R, Martín-Gutiérrez D, Diez-Alarcia R, Vilaró MT, Cortés R, García-Font N, Martín R, Espina M, Botta J, Ginés S, McCormick PJ, Sánchez-Prieto J, Galve-Roperh I, Mengod G, Urigüen L, Marsicano G, Bellocchio L, Canela EI, Casadó V, Rodríguez-Crespo I, Guzmán M. Costas-Insua C, et al. Among authors: mccormick pj. J Neurosci. 2021 Sep 22;41(38):7924-7941. doi: 10.1523/JNEUROSCI.0821-21.2021. Epub 2021 Aug 5. J Neurosci. 2021. PMID: 34353897 Free PMC article.
175 results