McCluskey A - Search Results

1

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.

Tremblay CS, Chiu SK, Saw J, McCalmont H, Litalien V, Boyle J, Sonderegger SE, Chau N, Evans K, Cerruti L, Salmon JM, McCluskey A, Lock RB, Robinson PJ, Jane SM, Curtis DJ. Tremblay CS, et al. Among authors: mccluskey a. Nat Commun. 2020 Dec 4;11(1):6211. doi: 10.1038/s41467-020-20091-6. Nat Commun. 2020. PMID: 33277497 Free PMC article.

2

Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity.

Hill TA, Odell LR, Quan A, Abagyan R, Ferguson G, Robinson PJ, McCluskey A. Hill TA, et al. Among authors: mccluskey a. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3275-8. doi: 10.1016/j.bmcl.2004.03.096. Bioorg Med Chem Lett. 2004. PMID: 15149689

3

Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins.

Hill T, Odell LR, Edwards JK, Graham ME, McGeachie AB, Rusak J, Quan A, Abagyan R, Scott JL, Robinson PJ, McCluskey A. Hill T, et al. Among authors: mccluskey a. J Med Chem. 2005 Dec 1;48(24):7781-8. doi: 10.1021/jm040208l. J Med Chem. 2005. PMID: 16302817

4

Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.

Quan A, McGeachie AB, Keating DJ, van Dam EM, Rusak J, Chau N, Malladi CS, Chen C, McCluskey A, Cousin MA, Robinson PJ. Quan A, et al. Among authors: mccluskey a. Mol Pharmacol. 2007 Dec;72(6):1425-39. doi: 10.1124/mol.107.034207. Epub 2007 Aug 16. Mol Pharmacol. 2007. PMID: 17702890

5

Steroids from an Australian sponge Psammoclema sp.

Holland IP, McCluskey A, Sakoff JA, Gilbert J, Chau N, Robinson PJ, Motti CA, Wright AD, van Altena IA. Holland IP, et al. Among authors: mccluskey a. J Nat Prod. 2009 Jan;72(1):102-6. doi: 10.1021/np800688f. J Nat Prod. 2009. PMID: 19132863

6

Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase.

Odell LR, Chau N, Mariana A, Graham ME, Robinson PJ, McCluskey A. Odell LR, et al. Among authors: mccluskey a. ChemMedChem. 2009 Jul;4(7):1182-8. doi: 10.1002/cmdc.200900054. ChemMedChem. 2009. PMID: 19437476

7

Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.

Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell LR, Chau N, Quan A, Mariana A, Sakoff JA, Chircop M, Robinson PJ, McCluskey A. Hill TA, et al. Among authors: mccluskey a. J Med Chem. 2009 Jun 25;52(12):3762-73. doi: 10.1021/jm900036m. J Med Chem. 2009. PMID: 19459681

8

Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.

Hill TA, Mariana A, Gordon CP, Odell LR, Robertson MJ, McGeachie AB, Chau N, Daniel JA, Gorgani NN, Robinson PJ, McCluskey A. Hill TA, et al. Among authors: mccluskey a. J Med Chem. 2010 May 27;53(10):4094-102. doi: 10.1021/jm100119c. J Med Chem. 2010. PMID: 20426422

9

Calcineurin activity is required for the completion of cytokinesis.

Chircop M, Malladi CS, Lian AT, Page SL, Zavortink M, Gordon CP, McCluskey A, Robinson PJ. Chircop M, et al. Among authors: mccluskey a. Cell Mol Life Sci. 2010 Nov;67(21):3725-37. doi: 10.1007/s00018-010-0401-z. Epub 2010 May 23. Cell Mol Life Sci. 2010. PMID: 20496096

10

The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.

Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M. Joshi S, et al. Among authors: mccluskey a. Mol Cancer Ther. 2010 Jul;9(7):1995-2006. doi: 10.1158/1535-7163.MCT-10-0161. Epub 2010 Jun 22. Mol Cancer Ther. 2010. PMID: 20571068

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