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Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.
Eschweiler S, Ramírez-Suástegui C, Li Y, King E, Chudley L, Thomas J, Wood O, von Witzleben A, Jeffrey D, McCann K, Simon H, Mondal M, Wang A, Dicker M, Lopez-Guadamillas E, Chou TF, Dobbs NA, Essame L, Acton G, Kelly F, Halbert G, Sacco JJ, Schache AG, Shaw R, McCaul JA, Paterson C, Davies JH, Brennan PA, Singh RP, Loadman PM, Wilson W, Hackshaw A, Seumois G, Okkenhaug K, Thomas GJ, Jones TM, Ay F, Friberg G, Kronenberg M, Vanhaesebroeck B, Vijayanand P, Ottensmeier CH. Eschweiler S, et al. Among authors: mccann k. Nature. 2022 May;605(7911):741-746. doi: 10.1038/s41586-022-04685-2. Epub 2022 May 4. Nature. 2022. PMID: 35508656 Free PMC article. Clinical Trial.
DNA vaccines to attack cancer.
Stevenson FK, Ottensmeier CH, Johnson P, Zhu D, Buchan SL, McCann KJ, Roddick JS, King AT, McNicholl F, Savelyeva N, Rice J. Stevenson FK, et al. Among authors: mccann kj. Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2(Suppl 2):14646-52. doi: 10.1073/pnas.0404896101. Epub 2004 Aug 3. Proc Natl Acad Sci U S A. 2004. PMID: 15292504 Free PMC article. Review.
Idiotype gene rescue in follicular lymphoma.
McCann K, Sahota SS, Stevenson FK, Ottensmeier CH. McCann K, et al. Methods Mol Med. 2005;115:145-71. doi: 10.1385/1-59259-936-2:145. Methods Mol Med. 2005. PMID: 15998967
DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time.
Chudley L, McCann K, Mander A, Tjelle T, Campos-Perez J, Godeseth R, Creak A, Dobbyn J, Johnson B, Bass P, Heath C, Kerr P, Mathiesen I, Dearnaley D, Stevenson F, Ottensmeier C. Chudley L, et al. Among authors: mccann k. Cancer Immunol Immunother. 2012 Nov;61(11):2161-70. doi: 10.1007/s00262-012-1270-0. Epub 2012 May 22. Cancer Immunol Immunother. 2012. PMID: 22729556 Free PMC article. Clinical Trial.
Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study.
McCann KJ, Godeseth R, Chudley L, Mander A, Di Genova G, Lloyd-Evans P, Kerr JP, Malykh VB, Jenner MW, Orchard KH, Stevenson FK, Ottensmeier CH. McCann KJ, et al. Cancer Immunol Immunother. 2015 Aug;64(8):1021-32. doi: 10.1007/s00262-015-1703-7. Epub 2015 May 16. Cancer Immunol Immunother. 2015. PMID: 25982371 Free PMC article. Clinical Trial.
Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.
McCann KJ, Mander A, Cazaly A, Chudley L, Stasakova J, Thirdborough S, King A, Lloyd-Evans P, Buxton E, Edwards C, Halford S, Bateman A, O'Callaghan A, Clive S, Anthoney A, Jodrell DI, Weinschenk T, Simon P, Sahin U, Thomas GJ, Stevenson FK, Ottensmeier CH. McCann KJ, et al. Clin Cancer Res. 2016 Oct 1;22(19):4827-4836. doi: 10.1158/1078-0432.CCR-15-2507. Epub 2016 Apr 18. Clin Cancer Res. 2016. PMID: 27091407 Free PMC article. Clinical Trial.
Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors.
Wood O, Woo J, Seumois G, Savelyeva N, McCann KJ, Singh D, Jones T, Peel L, Breen MS, Ward M, Garrido Martin E, Sanchez-Elsner T, Thomas G, Vijayanand P, Woelk CH, King E, Ottensmeier C; SPARC Consortium. Wood O, et al. Oncotarget. 2016 Aug 30;7(35):56781-56797. doi: 10.18632/oncotarget.10788. Oncotarget. 2016. PMID: 27462861 Free PMC article.
370 results