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Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer.
Cappellesso F, Orban MP, Shirgaonkar N, Berardi E, Serneels J, Neveu MA, Di Molfetta D, Piccapane F, Caroppo R, Debellis L, Ostyn T, Joudiou N, Mignion L, Richiardone E, Jordan BF, Gallez B, Corbet C, Roskams T, DasGupta R, Tejpar S, Di Matteo M, Taverna D, Reshkin SJ, Topal B, Virga F, Mazzone M. Cappellesso F, et al. Among authors: mazzone m. Nat Cancer. 2022 Dec;3(12):1464-1483. doi: 10.1038/s43018-022-00470-2. Epub 2022 Dec 15. Nat Cancer. 2022. PMID: 36522548 Free PMC article.
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.
Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De Palma M, Mazzone M. Takeda Y, et al. Among authors: mazzone m. Nature. 2011 Oct 9;479(7371):122-6. doi: 10.1038/nature10507. Nature. 2011. PMID: 21983962 Free PMC article.
Overcoming resistance to antiangiogenic therapies.
Tejpar S, Prenen H, Mazzone M. Tejpar S, et al. Among authors: mazzone m. Oncologist. 2012;17(8):1039-50. doi: 10.1634/theoncologist.2012-0068. Epub 2012 Jul 6. Oncologist. 2012. PMID: 22773560 Free PMC article. Review.
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.
Laoui D, Van Overmeire E, Di Conza G, Aldeni C, Keirsse J, Morias Y, Movahedi K, Houbracken I, Schouppe E, Elkrim Y, Karroum O, Jordan B, Carmeliet P, Gysemans C, De Baetselier P, Mazzone M, Van Ginderachter JA. Laoui D, et al. Among authors: mazzone m. Cancer Res. 2014 Jan 1;74(1):24-30. doi: 10.1158/0008-5472.CAN-13-1196. Epub 2013 Nov 12. Cancer Res. 2014. PMID: 24220244
MET is required for the recruitment of anti-tumoural neutrophils.
Finisguerra V, Di Conza G, Di Matteo M, Serneels J, Costa S, Thompson AA, Wauters E, Walmsley S, Prenen H, Granot Z, Casazza A, Mazzone M. Finisguerra V, et al. Among authors: mazzone m. Nature. 2015 Jun 18;522(7556):349-53. doi: 10.1038/nature14407. Epub 2015 May 18. Nature. 2015. PMID: 25985180 Free PMC article.
Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis.
Wenes M, Shang M, Di Matteo M, Goveia J, Martín-Pérez R, Serneels J, Prenen H, Ghesquière B, Carmeliet P, Mazzone M. Wenes M, et al. Among authors: mazzone m. Cell Metab. 2016 Nov 8;24(5):701-715. doi: 10.1016/j.cmet.2016.09.008. Epub 2016 Oct 20. Cell Metab. 2016. PMID: 27773694 Free article.
The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.
Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, Kiss M, Bolli E, Lahmar Q, Sichien D, Serneels J, Scott CL, Boon L, De Baetselier P, Mazzone M, Guilliams M, Van Ginderachter JA. Laoui D, et al. Among authors: mazzone m. Nat Commun. 2016 Dec 23;7:13720. doi: 10.1038/ncomms13720. Nat Commun. 2016. PMID: 28008905 Free PMC article.
The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.
Di Conza G, Trusso Cafarello S, Loroch S, Mennerich D, Deschoemaeker S, Di Matteo M, Ehling M, Gevaert K, Prenen H, Zahedi RP, Sickmann A, Kietzmann T, Moretti F, Mazzone M. Di Conza G, et al. Among authors: mazzone m. Cell Rep. 2017 Feb 14;18(7):1699-1712. doi: 10.1016/j.celrep.2017.01.051. Cell Rep. 2017. PMID: 28199842 Free PMC article.
282 results