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PI3K/mTOR inhibition induces tumour microenvironment remodelling and sensitises pS6high uterine leiomyosarcoma to PD-1 blockade.
De Wispelaere W, Annibali D, Tuyaerts S, Messiaen J, Antoranz A, Shankar G, Dubroja N, Herreros-Pomares A, Baiden-Amissah REM, Orban MP, Delfini M, Berardi E, Van Brussel T, Schepers R, Philips G, Boeckx B, Baietti MF, Congedo L, HoWangYin KY, Bayon E, Van Rompuy AS, Leucci E, Tabruyn SP, Bosisio F, Mazzone M, Lambrechts D, Amant F. De Wispelaere W, et al. Among authors: mazzone m. Clin Transl Med. 2024 May;14(5):e1655. doi: 10.1002/ctm2.1655. Clin Transl Med. 2024. PMID: 38711203 Free PMC article.
A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer.
Pinioti S, Sharma H, Flerin NC, Yu Q, Tzoumpa A, Trusso Cafarello S, De Bousser E, Callewaert N, Oldenhove G, Schlenner S, Thienpont B, Garg AD, Di Matteo M, Mazzone M. Pinioti S, et al. Among authors: mazzone m. Cancer Immunol Res. 2023 Dec 1;11(12):1611-1629. doi: 10.1158/2326-6066.CIR-22-0606. Cancer Immunol Res. 2023. PMID: 37933083
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding.
Riera-Domingo C, Leite-Gomes E, Charatsidou I, Zhao P, Carrá G, Cappellesso F, Mourao L, De Schepper M, Liu D, Serneels J, Alameh MG, Shuvaev VV, Geukens T, Isnaldi E, Prenen H, Weissman D, Muzykantov VR, Soenen S, Desmedt C, Scheele CLGJ, Sablina A, Di Matteo M, Martín-Pérez R, Mazzone M. Riera-Domingo C, et al. Among authors: mazzone m. Sci Adv. 2023 Mar 22;9(12):eadd5028. doi: 10.1126/sciadv.add5028. Epub 2023 Mar 22. Sci Adv. 2023. PMID: 36947620 Free PMC article.
282 results