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Hexylether derivative of pyropheophorbide-a (HPPH) on conjugating with 3gadolinium(III) aminobenzyldiethylenetriaminepentaacetic acid shows potential for in vivo tumor imaging (MR, Fluorescence) and photodynamic therapy.
Spernyak JA, White WH 3rd, Ethirajan M, Patel NJ, Goswami L, Chen Y, Turowski S, Missert JR, Batt C, Mazurchuk R, Pandey RK. Spernyak JA, et al. Among authors: mazurchuk r. Bioconjug Chem. 2010 May 19;21(5):828-35. doi: 10.1021/bc9005317. Bioconjug Chem. 2010. PMID: 20387862 Free PMC article.
Synthesis of Tumor-avid Photosensitizer-Gd(III)DTPA conjugates: impact of the number of gadolinium units in T1/T2 relaxivity, intracellular localization, and photosensitizing efficacy.
Goswami LN, White WH 3rd, Spernyak JA, Ethirajan M, Chen Y, Missert JR, Morgan J, Mazurchuk R, Pandey RK. Goswami LN, et al. Among authors: mazurchuk r. Bioconjug Chem. 2010 May 19;21(5):816-27. doi: 10.1021/bc9005305. Bioconjug Chem. 2010. PMID: 20387863 Free PMC article.
Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia, limited drug delivery, and resistance to irinotecan therapy.
Bhattacharya A, Tóth K, Mazurchuk R, Spernyak JA, Slocum HK, Pendyala L, Azrak R, Cao S, Durrani FA, Rustum YM. Bhattacharya A, et al. Among authors: mazurchuk r. Clin Cancer Res. 2004 Dec 1;10(23):8005-17. doi: 10.1158/1078-0432.CCR-04-1306. Clin Cancer Res. 2004. PMID: 15585636
40 results