Maxwell A - Search Results

1

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.

Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, Cao S, Garoff L, Berruga Fernández T, Giachou P, Crone L, Simoff I, Svensson R, Birnir B, Korol SV, Jin Z, Vicente F, Ramos MC, de la Cruz M, Glinghammar B, Lenhammar L, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Janssen GV, Sterk GJ, Kikelj D. Cotman AE, et al. Among authors: maxwell a. J Med Chem. 2023 Jan 26;66(2):1380-1425. doi: 10.1021/acs.jmedchem.2c01597. Epub 2023 Jan 12. J Med Chem. 2023. PMID: 36634346 Free PMC article.

2

The additional 165 amino acids in the B protein of Escherichia coli DNA gyrase have an important role in DNA binding.

Chatterji M, Unniraman S, Maxwell A, Nagaraja V. Chatterji M, et al. Among authors: maxwell a. J Biol Chem. 2000 Jul 28;275(30):22888-94. doi: 10.1074/jbc.M001047200. J Biol Chem. 2000. PMID: 10764756 Free article.

3

The ATP-binding site of type II topoisomerases as a target for antibacterial drugs.

Maxwell A, Lawson DM. Maxwell A, et al. Curr Top Med Chem. 2003;3(3):283-303. doi: 10.2174/1568026033452500. Curr Top Med Chem. 2003. PMID: 12570764 Review.

4

The action of the bacterial toxin microcin B17. Insight into the cleavage-religation reaction of DNA gyrase.

Pierrat OA, Maxwell A. Pierrat OA, et al. Among authors: maxwell a. J Biol Chem. 2003 Sep 12;278(37):35016-23. doi: 10.1074/jbc.M304516200. Epub 2003 Jun 25. J Biol Chem. 2003. PMID: 12829716 Free article.

5

Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondria.

Wall MK, Mitchenall LA, Maxwell A. Wall MK, et al. Among authors: maxwell a. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7821-6. doi: 10.1073/pnas.0400836101. Epub 2004 May 10. Proc Natl Acad Sci U S A. 2004. PMID: 15136745 Free PMC article.

6

A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.

Manjunatha UH, Maxwell A, Nagaraja V. Manjunatha UH, et al. Among authors: maxwell a. Nucleic Acids Res. 2005 Jun 1;33(10):3085-94. doi: 10.1093/nar/gki622. Print 2005. Nucleic Acids Res. 2005. PMID: 15930158 Free PMC article.

7

Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis.

Flatman RH, Eustaquio A, Li SM, Heide L, Maxwell A. Flatman RH, et al. Among authors: maxwell a. Antimicrob Agents Chemother. 2006 Apr;50(4):1136-42. doi: 10.1128/AAC.50.4.1136-1142.2006. Antimicrob Agents Chemother. 2006. PMID: 16569821 Free PMC article.

8

High-throughput assays for DNA gyrase and other topoisomerases.

Maxwell A, Burton NP, O'Hagan N. Maxwell A, et al. Nucleic Acids Res. 2006;34(15):e104. doi: 10.1093/nar/gkl504. Epub 2006 Aug 26. Nucleic Acids Res. 2006. PMID: 16936317 Free PMC article.

9

A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site.

Smith AB, Maxwell A. Smith AB, et al. Among authors: maxwell a. Nucleic Acids Res. 2006;34(17):4667-76. doi: 10.1093/nar/gkl636. Epub 2006 Sep 8. Nucleic Acids Res. 2006. PMID: 16963775 Free PMC article.

10

Crystallization and preliminary X-ray analysis of a complex formed between the antibiotic simocyclinone D8 and the DNA breakage-reunion domain of Escherichia coli DNA gyrase.

Edwards MJ, Flatman RH, Mitchenall LA, Stevenson CE, Maxwell A, Lawson DM. Edwards MJ, et al. Among authors: maxwell a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):846-8. doi: 10.1107/S1744309109028097. Epub 2009 Jul 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19652356 Free PMC article.

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