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Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.
Khanna D, Lin CJF, Furst DE, Goldin J, Kim G, Kuwana M, Allanore Y, Matucci-Cerinic M, Distler O, Shima Y, van Laar JM, Spotswood H, Wagner B, Siegel J, Jahreis A, Denton CP; focuSSced investigators. Khanna D, et al. Lancet Respir Med. 2020 Oct;8(10):963-974. doi: 10.1016/S2213-2600(20)30318-0. Epub 2020 Aug 28. Lancet Respir Med. 2020. PMID: 32866440 Clinical Trial.
Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers.
Distler O, Del Rosso A, Giacomelli R, Cipriani P, Conforti ML, Guiducci S, Gay RE, Michel BA, Brühlmann P, Müller-Ladner U, Gay S, Matucci-Cerinic M. Distler O, et al. Arthritis Res. 2002;4(6):R11. doi: 10.1186/ar596. Epub 2002 Aug 30. Arthritis Res. 2002. PMID: 12453314 Free PMC article.
Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways.
Distler JH, Hagen C, Hirth A, Müller-Ladner U, Lorenz HM, del Rosso A, Michel BA, Gay RE, Nanagara R, Nishioka K, Matucci-Cerinic M, Kalden JR, Gay S, Distler O. Distler JH, et al. Mol Pharmacol. 2004 Feb;65(2):389-99. doi: 10.1124/mol.65.2.389. Mol Pharmacol. 2004. PMID: 14742681
Connective tissue diseases.
Furst DE, Matucci Cerinic M. Furst DE, et al. Best Pract Res Clin Rheumatol. 2007 Dec;21(6):969-70. doi: 10.1016/j.berh.2007.11.001. Best Pract Res Clin Rheumatol. 2007. PMID: 18068855 No abstract available.
890 results