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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther. 2010 Dec 29;2(6):36. doi: 10.1186/alzrt60.
Alzheimers Res Ther. 2010.
PMID: 21190552
Free PMC article.
Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Mattson MN, Neitzel ML, Quincy DA, Semko CM, Garofalo AW, Keim PS, Konradi AW, Pleiss MA, Sham HL, Brigham EF, Goldbach EG, Zhang H, Sauer JM, Basi GS.
Mattson MN, et al.
Bioorg Med Chem Lett. 2010 Apr 1;20(7):2148-50. doi: 10.1016/j.bmcl.2010.02.050. Epub 2010 Feb 14.
Bioorg Med Chem Lett. 2010.
PMID: 20206516
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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Aubele DL, Truong AP, Dressen DB, Probst GD, Bowers S, Mattson MN, Semko CM, Sun M, Garofalo AW, Konradi AW, Sham HL, Zmolek W, Wong K, Goldbach E, Quinn KP, Sauer JM, Brigham EF, Wallace W, Nguyen L, Bova MP, Hemphill SS, Basi G.
Aubele DL, et al. Among authors: mattson mn.
Bioorg Med Chem Lett. 2011 Oct 1;21(19):5791-4. doi: 10.1016/j.bmcl.2011.08.008. Epub 2011 Aug 9.
Bioorg Med Chem Lett. 2011.
PMID: 21885276
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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Probst G, Aubele DL, Bowers S, Dressen D, Garofalo AW, Hom RK, Konradi AW, Marugg JL, Mattson MN, Neitzel ML, Semko CM, Sham HL, Smith J, Sun M, Truong AP, Ye XM, Xu YZ, Dappen MS, Jagodzinski JJ, Keim PS, Peterson B, Latimer LH, Quincy D, Wu J, Goldbach E, Ness DK, Quinn KP, Sauer JM, Wong K, Zhang H, Zmolek W, Brigham EF, Kholodenko D, Hu K, Kwong GT, Lee M, Liao A, Motter RN, Sacayon P, Santiago P, Willits C, Bard F, Bova MP, Hemphill SS, Nguyen L, Ruslim L, Tanaka K, Tanaka P, Wallace W, Yednock TA, Basi GS.
Probst G, et al. Among authors: mattson mn.
J Med Chem. 2013 Jul 11;56(13):5261-74. doi: 10.1021/jm301741t. Epub 2013 Jun 20.
J Med Chem. 2013.
PMID: 23713656
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The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide.
Bova MP, Mattson MN, Vasile S, Tam D, Holsinger L, Bremer M, Hui T, McMahon G, Rice A, Fukuto JM.
Bova MP, et al. Among authors: mattson mn.
Arch Biochem Biophys. 2004 Sep 1;429(1):30-41. doi: 10.1016/j.abb.2004.05.010.
Arch Biochem Biophys. 2004.
PMID: 15288807
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Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.
Bova MP, Tam D, McMahon G, Mattson MN.
Bova MP, et al. Among authors: mattson mn.
Toxicol Lett. 2005 Jan 15;155(1):41-50. doi: 10.1016/j.toxlet.2004.08.009.
Toxicol Lett. 2005.
PMID: 15585358
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Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate.
Holden KG, Mattson MN, Cha KH, Rapoport H.
Holden KG, et al. Among authors: mattson mn.
J Org Chem. 2002 Aug 23;67(17):5913-8. doi: 10.1021/jo0111210.
J Org Chem. 2002.
PMID: 12182622
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