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Gout.
Dalbeth N, Choi HK, Joosten LAB, Khanna PP, Matsuo H, Perez-Ruiz F, Stamp LK. Dalbeth N, et al. Among authors: matsuo h. Nat Rev Dis Primers. 2019 Sep 26;5(1):69. doi: 10.1038/s41572-019-0115-y. Nat Rev Dis Primers. 2019. PMID: 31558729 Review.
Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.
Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Hamajima N, Shinomiya N. Matsuo H, et al. Sci Transl Med. 2009 Nov 4;1(5):5ra11. doi: 10.1126/scitranslmed.3000237. Sci Transl Med. 2009. PMID: 20368174
Identification of ABCG2 dysfunction as a major factor contributing to gout.
Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Takada Y, Okada C, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Shinomiya N. Matsuo H, et al. Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1098-104. doi: 10.1080/15257770.2011.627902. Nucleosides Nucleotides Nucleic Acids. 2011. PMID: 22132963
ABCG2/BCRP dysfunction as a major cause of gout.
Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Suzuki H, Hosoya T, Shinomiya N. Matsuo H, et al. Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1117-28. doi: 10.1080/15257770.2011.633954. Nucleosides Nucleotides Nucleic Acids. 2011. PMID: 22132966
Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.
Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Inoue H, Oikawa Y, Naito M, Hishida A, Wakai K, Okada C, Shimizu S, Sakiyama M, Chiba T, Ogata H, Niwa K, Hosoyamada M, Mori A, Hamajima N, Suzuki H, Kanai Y, Sakurai Y, Hosoya T, Shimizu T, Shinomiya N. Matsuo H, et al. Sci Rep. 2013;3:2014. doi: 10.1038/srep02014. Sci Rep. 2013. PMID: 23774753 Free PMC article.
Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility.
Nakayama A, Matsuo H, Shimizu T, Ogata H, Takada Y, Nakashima H, Nakamura T, Shimizu S, Chiba T, Sakiyama M, Ushiyama C, Takada T, Inoue K, Kawai S, Hishida A, Wakai K, Hamajima N, Ichida K, Sakurai Y, Kato Y, Shimizu T, Shinomiya N. Nakayama A, et al. Among authors: matsuo h. Hum Cell. 2013 Dec;26(4):133-6. doi: 10.1007/s13577-013-0073-8. Epub 2013 Aug 29. Hum Cell. 2013. PMID: 23990105 Free PMC article.
A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout.
Sakiyama M, Matsuo H, Shimizu S, Nakashima H, Nakayama A, Chiba T, Naito M, Takada T, Suzuki H, Hamajima N, Ichida K, Shimizu T, Shinomiya N. Sakiyama M, et al. Among authors: matsuo h. Drug Metab Pharmacokinet. 2014;29(2):208-10. doi: 10.2133/dmpk.dmpk-13-nt-070. Epub 2013 Sep 10. Drug Metab Pharmacokinet. 2014. PMID: 24025986 Free article.
Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility.
Sakiyama M, Matsuo H, Shimizu S, Chiba T, Nakayama A, Takada Y, Nakamura T, Takada T, Morita E, Naito M, Wakai K, Inoue H, Tatsukawa S, Sato J, Shimono K, Makino T, Satoh T, Suzuki H, Kanai Y, Hamajima N, Sakurai Y, Ichida K, Shimizu T, Shinomiya N. Sakiyama M, et al. Among authors: matsuo h. Hum Cell. 2014 Jan;27(1):1-4. doi: 10.1007/s13577-013-0081-8. Epub 2013 Dec 7. Hum Cell. 2014. PMID: 24318514 Free PMC article.
NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout.
Chiba T, Matsuo H, Kawamura Y, Nagamori S, Nishiyama T, Wei L, Nakayama A, Nakamura T, Sakiyama M, Takada T, Taketani Y, Suma S, Naito M, Oda T, Kumagai H, Moriyama Y, Ichida K, Shimizu T, Kanai Y, Shinomiya N. Chiba T, et al. Among authors: matsuo h. Arthritis Rheumatol. 2015 Jan;67(1):281-7. doi: 10.1002/art.38884. Arthritis Rheumatol. 2015. PMID: 25252215
2,257 results