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Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).
Sekimata K, Sato T, Sakai N, Watanabe H, Mishima-Tsumagari C, Taguri T, Matsumoto T, Fujii Y, Handa N, Honma T, Tanaka A, Shirouzu M, Yokoyama S, Miyazono K, Hashizume Y, Koyama H. Sekimata K, et al. Among authors: matsumoto t. Chem Pharm Bull (Tokyo). 2019;67(3):224-235. doi: 10.1248/cpb.c18-00598. Chem Pharm Bull (Tokyo). 2019. PMID: 30828000 Free article.
Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast.
Umehara T, Otta Y, Tsuganezawa K, Matsumoto T, Tanaka A, Horikoshi M, Padmanabhan B, Yokoyama S. Umehara T, et al. Among authors: matsumoto t. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt 11):971-3. doi: 10.1107/S1744309105030927. Epub 2005 Oct 20. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511210 Free PMC article.
Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4.
Nakamura Y, Umehara T, Nakano K, Jang MK, Shirouzu M, Morita S, Uda-Tochio H, Hamana H, Terada T, Adachi N, Matsumoto T, Tanaka A, Horikoshi M, Ozato K, Padmanabhan B, Yokoyama S. Nakamura Y, et al. Among authors: matsumoto t. J Biol Chem. 2007 Feb 9;282(6):4193-201. doi: 10.1074/jbc.M605971200. Epub 2006 Dec 5. J Biol Chem. 2007. PMID: 17148447 Free article.
Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.
Sato T, Sekimata K, Sakai N, Watanabe H, Mishima-Tsumagari C, Taguri T, Matsumoto T, Fujii Y, Handa N, Tanaka A, Shirouzu M, Yokoyama S, Hashizume Y, Miyazono K, Koyama H, Honma T. Sato T, et al. Among authors: matsumoto t. ACS Omega. 2020 May 12;5(20):11411-11423. doi: 10.1021/acsomega.9b04245. eCollection 2020 May 26. ACS Omega. 2020. PMID: 32478230 Free PMC article.
Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer.
Takahashi K, Akatsu Y, Podyma-Inoue KA, Matsumoto T, Takahashi H, Yoshimatsu Y, Koinuma D, Shirouzu M, Miyazono K, Watabe T. Takahashi K, et al. Among authors: matsumoto t. J Biol Chem. 2020 Sep 4;295(36):12559-12572. doi: 10.1074/jbc.RA120.012492. Epub 2020 Jul 6. J Biol Chem. 2020. PMID: 32631954 Free PMC article.
Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva.
Yamamoto H, Sakai N, Ohte S, Sato T, Sekimata K, Matsumoto T, Nakamura K, Watanabe H, Mishima-Tsumagari C, Tanaka A, Hashizume Y, Honma T, Katagiri T, Miyazono K, Tomoda H, Shirouzu M, Koyama H. Yamamoto H, et al. Among authors: matsumoto t. Bioorg Med Chem Lett. 2021 Apr 15;38:127858. doi: 10.1016/j.bmcl.2021.127858. Epub 2021 Feb 18. Bioorg Med Chem Lett. 2021. PMID: 33609658
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