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Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1.
May O, Merle NS, Grunenwald A, Gnemmi V, Leon J, Payet C, Robe-Rybkine T, Paule R, Delguste F, Satchell SC, Mathieson PW, Hazzan M, Boulanger E, Dimitrov JD, Fremeaux-Bacchi V, Frimat M, Roumenina LT. May O, et al. Among authors: mathieson pw. Front Immunol. 2018 Dec 20;9:3008. doi: 10.3389/fimmu.2018.03008. eCollection 2018. Front Immunol. 2018. PMID: 30619356 Free PMC article.
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome.
Roumenina LT, Jablonski M, Hue C, Blouin J, Dimitrov JD, Dragon-Durey MA, Cayla M, Fridman WH, Macher MA, Ribes D, Moulonguet L, Rostaing L, Satchell SC, Mathieson PW, Sautes-Fridman C, Loirat C, Regnier CH, Halbwachs-Mecarelli L, Fremeaux-Bacchi V. Roumenina LT, et al. Among authors: mathieson pw. Blood. 2009 Sep 24;114(13):2837-45. doi: 10.1182/blood-2009-01-197640. Epub 2009 Jul 7. Blood. 2009. PMID: 19584399 Free article.
A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.
Roumenina LT, Frimat M, Miller EC, Provot F, Dragon-Durey MA, Bordereau P, Bigot S, Hue C, Satchell SC, Mathieson PW, Mousson C, Noel C, Sautes-Fridman C, Halbwachs-Mecarelli L, Atkinson JP, Lionet A, Fremeaux-Bacchi V. Roumenina LT, et al. Among authors: mathieson pw. Blood. 2012 May 3;119(18):4182-91. doi: 10.1182/blood-2011-10-383281. Epub 2012 Jan 13. Blood. 2012. PMID: 22246034 Free PMC article.
220 results