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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG Jr, McBrayer SK. Shi DD, et al. Among authors: mathews tp. Cancer Cell. 2022 Sep 12;40(9):939-956.e16. doi: 10.1016/j.ccell.2022.07.011. Epub 2022 Aug 18. Cancer Cell. 2022. PMID: 35985343 Free PMC article.
Metabolic heterogeneity confers differences in melanoma metastatic potential.
Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ, Morrison SJ. Tasdogan A, et al. Among authors: mathews tp. Nature. 2020 Jan;577(7788):115-120. doi: 10.1038/s41586-019-1847-2. Epub 2019 Dec 18. Nature. 2020. PMID: 31853067 Free PMC article.
Lymph protects metastasizing melanoma cells from ferroptosis.
Ubellacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell EC, Martin-Sandoval MS, Gu Z, McCormick ML, Durham AB, Spitz DR, Zhao Z, Mathews TP, Morrison SJ. Ubellacker JM, et al. Among authors: mathews tp. Nature. 2020 Sep;585(7823):113-118. doi: 10.1038/s41586-020-2623-z. Epub 2020 Aug 19. Nature. 2020. PMID: 32814895 Free PMC article.
Stable isotope tracing to assess tumor metabolism in vivo.
Faubert B, Tasdogan A, Morrison SJ, Mathews TP, DeBerardinis RJ. Faubert B, et al. Among authors: mathews tp. Nat Protoc. 2021 Nov;16(11):5123-5145. doi: 10.1038/s41596-021-00605-2. Epub 2021 Sep 17. Nat Protoc. 2021. PMID: 34535790 Free PMC article. Review.
45 results