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Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-a]pyrimidines.
Pacetti M, Pismataro MC, Felicetti T, Giammarino F, Bonomini A, Tiecco M, Bertagnin C, Barreca ML, Germani R, Cecchetti V, Vicenti I, Tabarrini O, Zazzi M, Loregian A, Massari S. Pacetti M, et al. Among authors: massari s. Org Biomol Chem. 2024 Jan 24;22(4):767-783. doi: 10.1039/d3ob01861j. Org Biomol Chem. 2024. PMID: 38167738
Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase.
Massari S, Bertagnin C, Pismataro MC, Donnadio A, Nannetti G, Felicetti T, Di Bona S, Nizi MG, Tensi L, Manfroni G, Loza MI, Sabatini S, Cecchetti V, Brea J, Goracci L, Loregian A, Tabarrini O. Massari S, et al. Eur J Med Chem. 2021 Jan 1;209:112944. doi: 10.1016/j.ejmech.2020.112944. Epub 2020 Oct 16. Eur J Med Chem. 2021. PMID: 33328103 Free PMC article.
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
Pismataro MC, Felicetti T, Bertagnin C, Nizi MG, Bonomini A, Barreca ML, Cecchetti V, Jochmans D, De Jonghe S, Neyts J, Loregian A, Tabarrini O, Massari S. Pismataro MC, et al. Among authors: massari s. Eur J Med Chem. 2021 Oct 5;221:113494. doi: 10.1016/j.ejmech.2021.113494. Epub 2021 Apr 26. Eur J Med Chem. 2021. PMID: 33962311
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.
Massari S, Nannetti G, Desantis J, Muratore G, Sabatini S, Manfroni G, Mercorelli B, Cecchetti V, Palù G, Cruciani G, Loregian A, Goracci L, Tabarrini O. Massari S, et al. J Med Chem. 2015 May 14;58(9):3830-42. doi: 10.1021/acs.jmedchem.5b00012. Epub 2015 Apr 20. J Med Chem. 2015. PMID: 25856229 Free article.
224 results