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Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202316133. doi: 10.1002/anie.202316133. Epub 2024 Feb 19.
Angew Chem Int Ed Engl. 2024.
PMID: 38279624
A kinase-cGAS cascade to synthesize a therapeutic STING activator.
McIntosh JA, Liu Z, Andresen BM, Marzijarani NS, Moore JC, Marshall NM, Borra-Garske M, Obligacion JV, Fier PS, Peng F, Forstater JH, Winston MS, An C, Chang W, Lim J, Huffman MA, Miller SP, Tsay FR, Altman MD, Lesburg CA, Steinhuebel D, Trotter BW, Cumming JN, Northrup A, Bu X, Mann BF, Biba M, Hiraga K, Murphy GS, Kolev JN, Makarewicz A, Pan W, Farasat I, Bade RS, Stone K, Duan D, Alvizo O, Adpressa D, Guetschow E, Hoyt E, Regalado EL, Castro S, Rivera N, Smith JP, Wang F, Crespo A, Verma D, Axnanda S, Dance ZEX, Devine PN, Tschaen D, Canada KA, Bulger PG, Sherry BD, Truppo MD, Ruck RT, Campeau LC, Bennett DJ, Humphrey GR, Campos KR, Maddess ML.
McIntosh JA, et al. Among authors: marzijarani ns.
Nature. 2022 Mar;603(7901):439-444. doi: 10.1038/s41586-022-04422-9. Epub 2022 Mar 16.
Nature. 2022.
PMID: 35296845
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A new tool to guide halofunctionalization reactions: the halenium affinity (HalA) scale.
Ashtekar KD, Marzijarani NS, Jaganathan A, Holmes D, Jackson JE, Borhan B.
Ashtekar KD, et al. Among authors: marzijarani ns.
J Am Chem Soc. 2014 Sep 24;136(38):13355-62. doi: 10.1021/ja506889c. Epub 2014 Sep 11.
J Am Chem Soc. 2014.
PMID: 25152188
Free PMC article.
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