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Identification of a critical binding site for local anaesthetics in the side pockets of Kv 1 channels.
Br J Pharmacol. 2021 Aug;178(15):3034-3048. doi: 10.1111/bph.15480. Epub 2021 May 14.
Br J Pharmacol. 2021.
PMID: 33817777
Free article.
Kvbeta1.3 reduces the degree of stereoselective bupivacaine block of Kv1.5 channels.
Arias C, Guizy M, David M, Marzian S, González T, Decher N, Valenzuela C.
Arias C, et al. Among authors: marzian s.
Anesthesiology. 2007 Oct;107(4):641-51. doi: 10.1097/01.anes.0000282100.32923.5c.
Anesthesiology. 2007.
PMID: 17893461
Free article.
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Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition.
Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N.
Marzian S, et al.
Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2.
Nat Chem Biol. 2013.
PMID: 23728494
Free PMC article.
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A leucine zipper motif essential for gating of hyperpolarization-activated channels.
Wemhöner K, Silbernagel N, Marzian S, Netter MF, Rinné S, Stansfeld PJ, Decher N.
Wemhöner K, et al. Among authors: marzian s.
J Biol Chem. 2012 Nov 23;287(48):40150-60. doi: 10.1074/jbc.M112.378513. Epub 2012 Oct 9.
J Biol Chem. 2012.
PMID: 23048023
Free PMC article.
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RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels.
Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Polanco RA, Preisig-Müller R, Klebe G, Budde T, Baukrowitz T, Daut J.
Decher N, et al. Among authors: marzian s.
EMBO J. 2010 Jul 7;29(13):2101-13. doi: 10.1038/emboj.2010.88. Epub 2010 May 11.
EMBO J. 2010.
PMID: 20461057
Free PMC article.
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