Maruhashi T - Search Results

1

LAG-3: from molecular functions to clinical applications.

Maruhashi T, Sugiura D, Okazaki IM, Okazaki T. Maruhashi T, et al. J Immunother Cancer. 2020 Sep;8(2):e001014. doi: 10.1136/jitc-2020-001014. J Immunother Cancer. 2020. PMID: 32929051 Free PMC article. Review.

2

LAG-3 inhibits the activation of CD4⁺ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.

Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, Okazaki T. Maruhashi T, et al. Nat Immunol. 2018 Dec;19(12):1415-1426. doi: 10.1038/s41590-018-0217-9. Epub 2018 Oct 22. Nat Immunol. 2018. PMID: 30349037

3

Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.

Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, Okazaki T. Maeda TK, et al. Among authors: maruhashi t. J Biol Chem. 2019 Apr 12;294(15):6017-6026. doi: 10.1074/jbc.RA119.007455. Epub 2019 Feb 13. J Biol Chem. 2019. PMID: 30760527 Free PMC article.

4

PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.

Mizuno R, Maruhashi T, Sugiura D, Shimizu K, Watada M, Okazaki IM, Okazaki T. Mizuno R, et al. Among authors: maruhashi t. Biochem Biophys Res Commun. 2019 Apr 9;511(3):491-497. doi: 10.1016/j.bbrc.2019.02.004. Epub 2019 Feb 14. Biochem Biophys Res Commun. 2019. PMID: 30771904

5

Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.

Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, Okazaki T. Sugiura D, et al. Among authors: maruhashi t. Science. 2019 May 10;364(6440):558-566. doi: 10.1126/science.aav7062. Epub 2019 Apr 18. Science. 2019. PMID: 31000591

6

PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation.

Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki IM, Okazaki T. Mizuno R, et al. Among authors: maruhashi t. Front Immunol. 2019 Mar 29;10:630. doi: 10.3389/fimmu.2019.00630. eCollection 2019. Front Immunol. 2019. PMID: 31001256 Free PMC article.

7

PD-1 aborts the activation trajectory of autoreactive CD8⁺ T cells to prohibit their acquisition of effector functions.

Okamura H, Okazaki IM, Shimizu K, Maruhashi T, Sugiura D, Mizuno R, Okazaki T. Okamura H, et al. Among authors: maruhashi t. J Autoimmun. 2019 Dec;105:102296. doi: 10.1016/j.jaut.2019.06.007. Epub 2019 Jul 2. J Autoimmun. 2019. PMID: 31277964 Free article.

8

Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells.

Maeda N, Maruhashi T, Sugiura D, Shimizu K, Okazaki IM, Okazaki T. Maeda N, et al. Among authors: maruhashi t. J Biol Chem. 2019 Dec 27;294(52):19896-19906. doi: 10.1074/jbc.RA119.010379. Epub 2019 Nov 13. J Biol Chem. 2019. PMID: 31723031 Free PMC article.

9

PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation.

Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takegami Y, Cheng C, Ozaki S, Okazaki T. Shimizu K, et al. Among authors: maruhashi t. Mol Cell. 2020 Mar 5;77(5):937-950.e6. doi: 10.1016/j.molcel.2019.12.012. Epub 2020 Jan 8. Mol Cell. 2020. PMID: 31926851 Free article.

10

PD-1 preferentially inhibits the activation of low-affinity T cells.

Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takemoto T, Okazaki T. Shimizu K, et al. Among authors: maruhashi t. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2107141118. doi: 10.1073/pnas.2107141118. Proc Natl Acad Sci U S A. 2021. PMID: 34433672 Free PMC article.

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