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The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?
Pavan C, Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison D, Lo Giudice C, Martra G, Montfort E, Schins R, Sulpizi M, Wegner K, Wyart-Remy M, Ziemann C, Turci F. Pavan C, et al. Among authors: martra g. Part Fibre Toxicol. 2019 Aug 16;16(1):32. doi: 10.1186/s12989-019-0315-3. Part Fibre Toxicol. 2019. PMID: 31419990 Free PMC article.
Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles.
Pavan C, Santalucia R, Leinardi R, Fabbiani M, Yakoub Y, Uwambayinema F, Ugliengo P, Tomatis M, Martra G, Turci F, Lison D, Fubini B. Pavan C, et al. Among authors: martra g. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):27836-27846. doi: 10.1073/pnas.2008006117. Epub 2020 Oct 23. Proc Natl Acad Sci U S A. 2020. PMID: 33097669 Free PMC article.
Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles.
Singh S, Shi T, Duffin R, Albrecht C, van Berlo D, Höhr D, Fubini B, Martra G, Fenoglio I, Borm PJ, Schins RP. Singh S, et al. Among authors: martra g. Toxicol Appl Pharmacol. 2007 Jul 15;222(2):141-51. doi: 10.1016/j.taap.2007.05.001. Epub 2007 May 18. Toxicol Appl Pharmacol. 2007. PMID: 17599375
68 results