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Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors.
Moghadasi SA, Heilmann E, Khalil AM, Nnabuife C, Kearns FL, Ye C, Moraes SN, Costacurta F, Esler MA, Aihara H, von Laer D, Martinez-Sobrido L, Palzkill T, Amaro RE, Harris RS. Moghadasi SA, et al. bioRxiv [Preprint]. 2022 Dec 26:2022.08.07.503099. doi: 10.1101/2022.08.07.503099. bioRxiv. 2022. PMID: 35982678 Free PMC article. Updated. Preprint.
Modeling SARS-CoV-2 and Influenza Infections and Antiviral Treatments in Human Lung Epithelial Tissue Equivalents.
Zarkoob H, Allué-Guardia A, Chen YC, Jung O, Garcia-Vilanova A, Song MJ, Park JG, Oladunni F, Miller J, Tung YT, Kosik I, Schultz D, Yewdell J, Torrelles JB, Martinez-Sobrido L, Cherry S, Ferrer M, Lee EM. Zarkoob H, et al. bioRxiv [Preprint]. 2021 May 12:2021.05.11.443693. doi: 10.1101/2021.05.11.443693. bioRxiv. 2021. PMID: 34013274 Free PMC article. Updated. Preprint.
Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.
Saul S, Karim M, Ghita L, Huang PT, Chiu W, Durán V, Lo CW, Kumar S, Bhalla N, Leyssen P, Alem F, Boghdeh NA, Tran DH, Cohen CA, Brown JA, Huie KE, Tindle C, Sibai M, Ye C, Khalil AM, Martinez-Sobrido L, Dye JM, Pinsky BA, Ghosh P, Das S, Solow-Cordero DE, Jin J, Wikswo JP, Jochmans D, Neyts J, Jonghe S, Narayanan A, Einav S. Saul S, et al. bioRxiv [Preprint]. 2023 May 10:2021.05.15.444128. doi: 10.1101/2021.05.15.444128. bioRxiv. 2023. PMID: 34159337 Free PMC article. Updated. Preprint.
Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody.
Piepenbrink MS, Park JG, Desphande A, Loos A, Ye C, Basu M, Sarkar S, Chauvin D, Woo J, Lovalenti P, Erdmann NB, Goepfert PA, Truong VL, Bowen RA, Walter MR, Martinez-Sobrido L, Kobie JJ. Piepenbrink MS, et al. bioRxiv [Preprint]. 2022 Mar 7:2022.03.05.483133. doi: 10.1101/2022.03.05.483133. bioRxiv. 2022. PMID: 35291292 Free PMC article. Updated. Preprint.
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.
Kehrer T, Cupic A, Ye C, Yildiz S, Bouhhadou M, Crossland NA, Barrall E, Cohen P, Tseng A, Çağatay T, Rathnasinghe R, Flores D, Jangra S, Alam F, Mena N, Aslam S, Saqi A, Marin A, Rutkowska M, Ummadi MR, Pisanelli G, Richardson RB, Veit EC, Fabius JM, Soucheray M, Polacco BJ, Evans MJ, Swaney DL, Gonzalez-Reiche AS, Sordillo EM, van Bakel H, Simon V, Zuliani-Alvarez L, Fontoura BMA, Rosenberg BR, Krogan NJ, Martinez-Sobrido L, García-Sastre A, Miorin L. Kehrer T, et al. bioRxiv [Preprint]. 2022 Nov 30:2022.10.18.512708. doi: 10.1101/2022.10.18.512708. bioRxiv. 2022. PMID: 36299428 Free PMC article. Updated. Preprint.
A new tractable method for generating Human Alveolar Macrophage Like cells in vitro to study lung inflammatory processes and diseases.
Pahari S, Arnett E, Simper J, Azad A, Guerrero-Arguero I, Ye C, Zhang H, Cai H, Wang Y, Lai Z, Jarvis N, Lumbreras M, Maselli-Caceres DJ, Peters J, Torrelles JB, Martinez-Sobrido L, Schlesinger LS. Pahari S, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.05.535806. doi: 10.1101/2023.04.05.535806. bioRxiv. 2023. PMID: 37066199 Free PMC article. Updated. Preprint.
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, O'Leary PC, Jogalekar MP, McCavitt-Malvido M, Diolaiti ME, Kimmerly GR, Tsou CL, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. Taha TY, et al. bioRxiv [Preprint]. 2023 May 10:2023.04.18.537104. doi: 10.1101/2023.04.18.537104. bioRxiv. 2023. PMID: 37131711 Free PMC article. Updated. Preprint.
295 results