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Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms.
MacKinnon S, Pagé V, Chen JJ, Shariat-Panahi A, Martin RD, Hébert TE, Tanny JC. MacKinnon S, et al. Among authors: martin rd. PLoS Genet. 2023 Nov 8;19(11):e1010492. doi: 10.1371/journal.pgen.1010492. eCollection 2023 Nov. PLoS Genet. 2023. PMID: 37939109 Free PMC article.
This separation of function argues that Spt5 CTD phosphorylation and CTD length restrict heterochromatin through unique mechanisms. More broadly, our findings argue that length and phosphorylation of the Spt5 CTD repeat array have distinct regulatory effects on transcripti …
This separation of function argues that Spt5 CTD phosphorylation and CTD length restrict heterochromatin through unique mechanisms. More …
How to maximise asynchronous video resources that have been co-produced with patient partners.
Martin R, Hardcastle S, Moyle B, Dowlman M, Williams A. Martin R, et al. Clin Teach. 2023 Dec;20(6):e13622. doi: 10.1111/tct.13622. Epub 2023 Oct 24. Clin Teach. 2023. PMID: 37874079
Ensuring that health professional education is person centred is vital in the pursuit of person-centred clinical care. However, the volume of person-centred care content varies broadly in health professional education. One acknowledged approach to designing curriculum that …
Ensuring that health professional education is person centred is vital in the pursuit of person-centred clinical care. However, the volume o …
Adaptation to urban environments.
Diamond SE, Prileson EG, Martin RA. Diamond SE, et al. Among authors: martin ra. Curr Opin Insect Sci. 2022 Jun;51:100893. doi: 10.1016/j.cois.2022.100893. Epub 2022 Feb 28. Curr Opin Insect Sci. 2022. PMID: 35240334 Review.
These data were drawn from phenotypic reciprocal transplant studies, the majority of which focus on insects and other arthropods. Broadly, we found support for local adaptation to urban and rural environments. ...
These data were drawn from phenotypic reciprocal transplant studies, the majority of which focus on insects and other arthropods. Broadly …
Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals.
Moldt B, Günthard HF, Workowski KA, Little SJ, Eron JJ, Overton ET, Lehmann C, Rokx C, Kozal MJ, Gandhi RT, Braun DL, Parvangada A, Li J, Martin R, Selzer L, Cox S, Margot N, Liu H, Slamowitz D, Makadzange T, Collins SE, Geleziunas R, Callebaut C. Moldt B, et al. Among authors: martin r. AIDS. 2022 Feb 1;36(2):205-214. doi: 10.1097/QAD.0000000000003088. AIDS. 2022. PMID: 34586088
Evaluation of Broadly Neutralizing Antibody Sensitivity by Genotyping and Phenotyping for Qualifying Participants to HIV Clinical Trials.
Moldt B, Parvangada A, Martin R, Pace C, Balakrishnan M, Thomsen ND, E Collins S, Kuster H, Braun DL, Günthard HF, Geleziunas R, Callebaut C. Moldt B, et al. Among authors: martin r. J Acquir Immune Defic Syndr. 2021 Sep 1;88(1):61-69. doi: 10.1097/QAI.0000000000002722. J Acquir Immune Defic Syndr. 2021. PMID: 34397744
BACKGROUND: HIV envelope (env) diversity represents a significant challenge for the use of broadly neutralizing antibodies (bNAbs) in HIV treatment and cure studies. ...
BACKGROUND: HIV envelope (env) diversity represents a significant challenge for the use of broadly neutralizing antibodies (bNAbs) in …
Adaptation and transcultural translation into Spanish of the Identification of Functional Ankle Instability questionnaire.
Izquierdo TG, León ES, Martín RT, Armero J, Rivas-Calvo P, Pecos-Martín D, Achalandabaso-Ochoa A, Rodríguez-Fernández ÁL. Izquierdo TG, et al. Among authors: martin rt. Musculoskelet Sci Pract. 2021 Apr;52:102339. doi: 10.1016/j.msksp.2021.102339. Epub 2021 Feb 3. Musculoskelet Sci Pract. 2021. PMID: 33582620
The English version of the identification functional ankle instability (IdFAI) questionnaire has been broadly used, but there is not a cross-cultural adaptation into Spanish. ...
The English version of the identification functional ankle instability (IdFAI) questionnaire has been broadly used, but there is not …
Development of Europe-Wide Models for Particle Elemental Composition Using Supervised Linear Regression and Random Forest.
Chen J, de Hoogh K, Gulliver J, Hoffmann B, Hertel O, Ketzel M, Weinmayr G, Bauwelinck M, van Donkelaar A, Hvidtfeldt UA, Atkinson R, Janssen NAH, Martin RV, Samoli E, Andersen ZJ, Oftedal BM, Stafoggia M, Bellander T, Strak M, Wolf K, Vienneau D, Brunekreef B, Hoek G. Chen J, et al. Among authors: martin rv. Environ Sci Technol. 2020 Dec 15;54(24):15698-15709. doi: 10.1021/acs.est.0c06595. Epub 2020 Nov 25. Environ Sci Technol. 2020. PMID: 33237771 Free PMC article.
Models differed substantially between elements regarding major predictor variables, broadly reflecting known sources. Agreement between the two algorithm predictions was generally high at the overall European level and varied substantially at the national level. ...
Models differed substantially between elements regarding major predictor variables, broadly reflecting known sources. Agreement betwe …
Examining PM2.5 concentrations and exposure using multiple models.
Kelly JT, Jang C, Timin B, Di Q, Schwartz J, Liu Y, van Donkelaar A, Martin RV, Berrocal V, Bell ML. Kelly JT, et al. Among authors: martin rv. Environ Res. 2021 May;196:110432. doi: 10.1016/j.envres.2020.110432. Epub 2020 Nov 7. Environ Res. 2021. PMID: 33166538 Free PMC article.
., but also considered 1-km predictions in sensitivity analyses. The exposure models predicted broadly consistent PM(2.5) concentrations, with relatively high concentrations on average over the eastern U.S. and greater variability in the western U.S. ...
., but also considered 1-km predictions in sensitivity analyses. The exposure models predicted broadly consistent PM(2.5) concentrati …
Therapeutic Targeting of the General RNA Polymerase II Transcription Machinery.
Martin RD, Hébert TE, Tanny JC. Martin RD, et al. Int J Mol Sci. 2020 May 9;21(9):3354. doi: 10.3390/ijms21093354. Int J Mol Sci. 2020. PMID: 32397434 Free PMC article. Review.
We discuss the effects of transcription inhibitors in vitro and in cellular models (with an emphasis on cancer), as well as their efficacy in preclinical and clinical studies. We also discuss the rationale for inhibiting broadly acting transcriptional regulators or RNAPII …
We discuss the effects of transcription inhibitors in vitro and in cellular models (with an emphasis on cancer), as well as their efficacy i …
Bayesian hierarchical EMAX model for dose-response in early phase efficacy clinical trials.
Gajewski BJ, Meinzer C, Berry SM, Rockswold GL, Barsan WG, Korley FK, Martin RH. Gajewski BJ, et al. Among authors: martin rh. Stat Med. 2019 Jul 30;38(17):3123-3138. doi: 10.1002/sim.8167. Epub 2019 May 9. Stat Med. 2019. PMID: 31070807 Free PMC article.
One very successful alternate model improves power using a pre-specified dose-response structure. Past research indicates that EMAX models are broadly successful and therefore attractive for designing dose-response trials. ...
One very successful alternate model improves power using a pre-specified dose-response structure. Past research indicates that EMAX models a …
25 results