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Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.
Shen YQ, Guerra-Librero A, Fernandez-Gil BI, Florido J, García-López S, Martinez-Ruiz L, Mendivil-Perez M, Soto-Mercado V, Acuña-Castroviejo D, Ortega-Arellano H, Carriel V, Diaz-Casado ME, Reiter RJ, Rusanova I, Nieto A, López LC, Escames G. Shen YQ, et al. J Pineal Res. 2018 Apr;64(3). doi: 10.1111/jpi.12461. Epub 2018 Jan 9. J Pineal Res. 2018. PMID: 29247557
Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy.
Fernandez-Gil BI, Guerra-Librero A, Shen YQ, Florido J, Martínez-Ruiz L, García-López S, Adan C, Rodríguez-Santana C, Acuña-Castroviejo D, Quiñones-Hinojosa A, Fernández-Martínez J, Abdel Moneim AE, López LC, Rodríguez Ferrer JM, Escames G. Fernandez-Gil BI, et al. Oxid Med Cell Longev. 2019 Feb 28;2019:7187128. doi: 10.1155/2019/7187128. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 30944696 Free PMC article.
Protective Effects of Melatonin on the Skin: Future Perspectives.
Rusanova I, Martínez-Ruiz L, Florido J, Rodríguez-Santana C, Guerra-Librero A, Acuña-Castroviejo D, Escames G. Rusanova I, et al. Int J Mol Sci. 2019 Oct 8;20(19):4948. doi: 10.3390/ijms20194948. Int J Mol Sci. 2019. PMID: 31597233 Free PMC article. Review.
Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function.
Guerra-Librero A, Fernandez-Gil BI, Florido J, Martinez-Ruiz L, Rodríguez-Santana C, Shen YQ, García-Verdugo JM, López-Rodríguez A, Rusanova I, Quiñones-Hinojosa A, Acuña-Castroviejo D, Marruecos J, De Haro T, Escames G. Guerra-Librero A, et al. Antioxidants (Basel). 2021 Apr 14;10(4):603. doi: 10.3390/antiox10040603. Antioxidants (Basel). 2021. PMID: 33919790 Free PMC article.
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport.
Florido J, Martinez-Ruiz L, Rodriguez-Santana C, López-Rodríguez A, Hidalgo-Gutiérrez A, Cottet-Rousselle C, Lamarche F, Schlattner U, Guerra-Librero A, Aranda-Martínez P, Acuña-Castroviejo D, López LC, Escames G. Florido J, et al. Among authors: martinez ruiz l. J Pineal Res. 2022 Oct;73(3):e12824. doi: 10.1111/jpi.12824. Epub 2022 Aug 28. J Pineal Res. 2022. PMID: 35986493 Free PMC article.
Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes.
Shao S, Scholtz LU, Gendreizig S, Martínez-Ruiz L, Florido J, Escames G, Schürmann M, Hain C, Hose L, Mentz A, Schmidt P, Wang M, Goon P, Wehmeier M, Brasch F, Kalinowski J, Oppel F, Sudhoff H. Shao S, et al. Among authors: martinez ruiz l. BMC Cancer. 2023 Jan 13;23(1):47. doi: 10.1186/s12885-022-10481-y. BMC Cancer. 2023. PMID: 36639629 Free PMC article.
Role of Melatonin in Cancer: Effect on Clock Genes.
Rodríguez-Santana C, Florido J, Martínez-Ruiz L, López-Rodríguez A, Acuña-Castroviejo D, Escames G. Rodríguez-Santana C, et al. Among authors: martinez ruiz l. Int J Mol Sci. 2023 Jan 18;24(3):1919. doi: 10.3390/ijms24031919. Int J Mol Sci. 2023. PMID: 36768253 Free PMC article. Review.
14 results