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Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3.
PLoS One. 2013 Apr 17;8(4):e60933. doi: 10.1371/journal.pone.0060933. Print 2013.
PLoS One. 2013.
PMID: 23613759
Free PMC article.
Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery.
Rebollo-Lopez MJ, Lelièvre J, Alvarez-Gomez D, Castro-Pichel J, Martínez-Jiménez F, Papadatos G, Kumar V, Colmenarejo G, Mugumbate G, Hurle M, Barroso V, Young RJ, Martinez-Hoyos M, González del Río R, Bates RH, Lopez-Roman EM, Mendoza-Losana A, Brown JR, Alvarez-Ruiz E, Marti-Renom MA, Overington JP, Cammack N, Ballell L, Barros-Aguire D.
Rebollo-Lopez MJ, et al. Among authors: martinez hoyos m.
PLoS One. 2015 Dec 7;10(12):e0142293. doi: 10.1371/journal.pone.0142293. eCollection 2015.
PLoS One. 2015.
PMID: 26642067
Free PMC article.
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Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.
Martínez-Hoyos M, Perez-Herran E, Gulten G, Encinas L, Álvarez-Gómez D, Alvarez E, Ferrer-Bazaga S, García-Pérez A, Ortega F, Angulo-Barturen I, Rullas-Trincado J, Blanco Ruano D, Torres P, Castañeda P, Huss S, Fernández Menéndez R, González Del Valle S, Ballell L, Barros D, Modha S, Dhar N, Signorino-Gelo F, McKinney JD, García-Bustos JF, Lavandera JL, Sacchettini JC, Jimenez MS, Martín-Casabona N, Castro-Pichel J, Mendoza-Losana A.
Martínez-Hoyos M, et al.
EBioMedicine. 2016 Jun;8:291-301. doi: 10.1016/j.ebiom.2016.05.006. Epub 2016 May 8.
EBioMedicine. 2016.
PMID: 27428438
Free PMC article.
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Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages.
Sorrentino F, Gonzalez del Rio R, Zheng X, Presa Matilla J, Torres Gomez P, Martinez Hoyos M, Perez Herran ME, Mendoza Losana A, Av-Gay Y.
Sorrentino F, et al. Among authors: martinez hoyos m.
Antimicrob Agents Chemother. 2015 Oct 26;60(1):640-5. doi: 10.1128/AAC.01920-15. Print 2016 Jan.
Antimicrob Agents Chemother. 2015.
PMID: 26503663
Free PMC article.
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New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.
Pajk S, Živec M, Šink R, Sosič I, Neu M, Chung CW, Martínez-Hoyos M, Pérez-Herrán E, Álvarez-Gómez D, Álvarez-Ruíz E, Mendoza-Losana A, Castro-Pichel J, Barros D, Ballell-Pages L, Young RJ, Convery MA, Encinas L, Gobec S.
Pajk S, et al. Among authors: martinez hoyos m.
Eur J Med Chem. 2016 Apr 13;112:252-257. doi: 10.1016/j.ejmech.2016.02.008. Epub 2016 Feb 8.
Eur J Med Chem. 2016.
PMID: 26900657
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N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J, Zhang T, Meiler E, Rees M, Somersan-Karakaya S, Porras-De Francisco E, Martinez-Hoyos M, Burns-Huang K, Roberts J, Ling Y, Rhee KY, Mendoza-Losana A, Luo M, Nathan CF.
Warrier T, et al. Among authors: martinez hoyos m.
Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4523-30. doi: 10.1073/pnas.1606590113. Epub 2016 Jul 18.
Proc Natl Acad Sci U S A. 2016.
PMID: 27432954
Free PMC article.
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Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis.
Warrier T, Martinez-Hoyos M, Marin-Amieva M, Colmenarejo G, Porras-De Francisco E, Alvarez-Pedraglio AI, Fraile-Gabaldon MT, Torres-Gomez PA, Lopez-Quezada L, Gold B, Roberts J, Ling Y, Somersan-Karakaya S, Little D, Cammack N, Nathan C, Mendoza-Losana A.
Warrier T, et al. Among authors: martinez hoyos m.
ACS Infect Dis. 2015 Dec 11;1(12):580-5. doi: 10.1021/acsinfecdis.5b00025. Epub 2015 Jun 22.
ACS Infect Dis. 2015.
PMID: 27623055
Free article.
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Functional screening of selective mitochondrial inhibitors of Plasmodium.
Gomez-Lorenzo MG, Rodríguez-Alejandre A, Moliner-Cubel S, Martínez-Hoyos M, Bahamontes-Rosa N, Gonzalez Del Rio R, Ródenas C, Fuente J, Lavandera JL, García-Bustos JF, Mendoza-Losana A.
Gomez-Lorenzo MG, et al. Among authors: martinez hoyos m.
Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):295-303. doi: 10.1016/j.ijpddr.2018.04.007. Epub 2018 May 9.
Int J Parasitol Drugs Drug Resist. 2018.
PMID: 29775797
Free PMC article.
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