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A highly efficient transgene knock-in technology in clinically relevant cell types.
Nat Biotechnol. 2024 Mar;42(3):458-469. doi: 10.1038/s41587-023-01779-8. Epub 2023 May 1.
Nat Biotechnol. 2024.
PMID: 37127662
Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.
Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD.
Nagel ZD, et al. Among authors: margulies cm.
Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1823-32. doi: 10.1073/pnas.1401182111. Epub 2014 Apr 22.
Proc Natl Acad Sci U S A. 2014.
PMID: 24757057
Free PMC article.
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Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus.
Bothmer A, Phadke T, Barrera LA, Margulies CM, Lee CS, Buquicchio F, Moss S, Abdulkerim HS, Selleck W, Jayaram H, Myer VE, Cotta-Ramusino C.
Bothmer A, et al. Among authors: margulies cm.
Nat Commun. 2017 Jan 9;8:13905. doi: 10.1038/ncomms13905.
Nat Commun. 2017.
PMID: 28067217
Free PMC article.
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Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
Vavassori V, Mercuri E, Marcovecchio GE, Castiello MC, Schiroli G, Albano L, Margulies C, Buquicchio F, Fontana E, Beretta S, Merelli I, Cappelleri A, Rancoita PM, Lougaris V, Plebani A, Kanariou M, Lankester A, Ferrua F, Scanziani E, Cotta-Ramusino C, Villa A, Naldini L, Genovese P.
Vavassori V, et al.
EMBO Mol Med. 2021 Mar 5;13(3):e13545. doi: 10.15252/emmm.202013545. Epub 2021 Jan 21.
EMBO Mol Med. 2021.
PMID: 33475257
Free PMC article.
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Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms.
Margulies CM, Chaim IA, Mazumder A, Criscione J, Samson LD.
Margulies CM, et al.
PLoS One. 2017 Sep 8;12(9):e0184619. doi: 10.1371/journal.pone.0184619. eCollection 2017.
PLoS One. 2017.
PMID: 28886188
Free PMC article.
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ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.
Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D.
Jordan JJ, et al. Among authors: margulies cm.
Cell Death Dis. 2017 Jul 20;8(7):e2947. doi: 10.1038/cddis.2017.343.
Cell Death Dis. 2017.
PMID: 28726787
Free PMC article.
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