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Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer.
Koo J, Seong CS, Parker RE, Dwivedi B, Arthur RA, Dinasarapu AR, Johnston HR, Claussen H, Tucker-Burden C, Ramalingam SS, Fu H, Zhou W, Marcus AI, Gilbert-Ross M. Koo J, et al. Among authors: marcus ai. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544941. doi: 10.1101/2023.06.14.544941. bioRxiv. 2023. PMID: 37398244 Free PMC article. Preprint.
Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.
Seong CS, Huang C, Boese AC, Hou Y, Koo J, Mouw JK, Rupji M, Joseph G, Johnston HR, Claussen H, Switchenko JM, Behera M, Churchman M, Kolesar JM, Arnold SM, Kerrigan K, Akerley W, Colman H, Johns MA, Arciero C, Zhou W, Marcus AI, Ramalingam SS, Fu H, Gilbert-Ross M. Seong CS, et al. Among authors: marcus ai. bioRxiv [Preprint]. 2023 Jan 27:2023.01.26.525772. doi: 10.1101/2023.01.26.525772. bioRxiv. 2023. PMID: 36747658 Free PMC article. Preprint.
Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning.
Summerbell ER, Mouw JK, Bell JSK, Knippler CM, Pedro B, Arnst JL, Khatib TO, Commander R, Barwick BG, Konen J, Dwivedi B, Seby S, Kowalski J, Vertino PM, Marcus AI. Summerbell ER, et al. Among authors: marcus ai. Sci Adv. 2020 Jul 24;6(30):eaaz6197. doi: 10.1126/sciadv.aaz6197. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832657 Free PMC article.
78 results