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IL-38 Gene Deletion Worsens Murine Colitis.
de Graaf DM, Wang RX, Amo-Aparicio J, Lee JS, Dowdell AS, Tengesdal IW, Marchetti C, Colgan SP, Joosten LAB, Dinarello CA. de Graaf DM, et al. Among authors: marchetti c. Front Immunol. 2022 May 26;13:840719. doi: 10.3389/fimmu.2022.840719. eCollection 2022. Front Immunol. 2022. PMID: 35693797 Free PMC article.
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. Marchetti C, et al. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29. Proc Natl Acad Sci U S A. 2018. PMID: 29378952 Free PMC article.
PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis.
Powers NE, Swartzwelter B, Marchetti C, de Graaf DM, Lerchner A, Schlapschy M, Datar R, Binder U, Edwards CK 3rd, Skerra A, Dinarello CA. Powers NE, et al. Among authors: marchetti c. J Biol Chem. 2020 Jan 17;295(3):868-882. doi: 10.1074/jbc.RA119.010340. Epub 2019 Dec 9. J Biol Chem. 2020. PMID: 31819009 Free PMC article.
Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial.
Klück V, Jansen TLTA, Janssen M, Comarniceanu A, Efdé M, Tengesdal IW, Schraa K, Cleophas MCP, Scribner CL, Skouras DB, Marchetti C, Dinarello CA, Joosten LAB. Klück V, et al. Among authors: marchetti c. Lancet Rheumatol. 2020 May;2(5):e270-e280. doi: 10.1016/s2665-9913(20)30065-5. Epub 2020 Apr 8. Lancet Rheumatol. 2020. PMID: 33005902 Free PMC article.
874 results